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Gene Review

Tinagl1  -  tubulointerstitial nephritis antigen-like 1

Mus musculus

Synonyms: 1110021J17Rik, AZ-1, AZ1, Adrenocortical zonation factor 1, Androgen-regulated gene 1 protein, ...
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Disease relevance of Tinagl


High impact information on Tinagl

  • Despite this difference in the androgenic regulation of integrated C3 rat genes, both type of cell lines still demonstrated androgen-regulated growth characteristics [6].
  • This study establishes gamma-8 as a critical protein for basal AMPA receptor expression and localization at extrasynaptic sites in the hippocampus and raises the possibility that TARP-dependent control of AMPA receptors during synapse development and plasticity may be widespread [7].
  • In brain regions that express multiple isoforms, such as cerebral cortex, TARP-AMPA receptor complexes are strictly segregated, suggesting distinct roles for TARP isoforms [8].
  • Expression of the homeobox gene Pem, which is androgen-regulated in SC, was severely decreased [9].
  • Arg-1, Gly-2, Val-4, Gln-6, and Gly-7 of the peptide were identified as putative TCR contact residues by testing the peptide analogs for their capacity to sensitize targets for VSV-specific cytolytic T-lymphocyte clones [10].

Chemical compound and disease context of Tinagl


Biological context of Tinagl


Anatomical context of Tinagl


Associations of Tinagl with chemical compounds


Physical interactions of Tinagl


Regulatory relationships of Tinagl


Other interactions of Tinagl


Analytical, diagnostic and therapeutic context of Tinagl


  1. Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia. Afar, D.E., Vivanco, I., Hubert, R.S., Kuo, J., Chen, E., Saffran, D.C., Raitano, A.B., Jakobovits, A. Cancer Res. (2001) [Pubmed]
  2. Interaction of androgen response elements with the DNA-binding domain of the rat androgen receptor expressed in Escherichia coli. De Vos, P., Claessens, F., Winderickx, J., Van Dijck, P., Celis, L., Peeters, B., Rombauts, W., Heyns, W., Verhoeven, G. J. Biol. Chem. (1991) [Pubmed]
  3. Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice. Schirmacher, P., Held, W.A., Yang, D., Biempica, L., Rogler, C.E. Am. J. Pathol. (1991) [Pubmed]
  4. FGF-8b increases angiogenic capacity and tumor growth of androgen-regulated S115 breast cancer cells. Mattila, M.M., Ruohola, J.K., Valve, E.M., Tasanen, M.J., Seppänen, J.A., Härkönen, P.L. Oncogene (2001) [Pubmed]
  5. Role of cadmium in the regulation of AR gene expression and activity. Martin, M.B., Voeller, H.J., Gelmann, E.P., Lu, J., Stoica, E.G., Hebert, E.J., Reiter, R., Singh, B., Danielsen, M., Pentecost, E., Stoica, A. Endocrinology (2002) [Pubmed]
  6. Androgen-regulated expression of a cloned rat prostatic c3 gene transfected into mouse mammary tumor cells. Page, M.J., Parker, M.G. Cell (1983) [Pubmed]
  7. TARP gamma-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity. Rouach, N., Byrd, K., Petralia, R.S., Elias, G.M., Adesnik, H., Tomita, S., Karimzadegan, S., Kealey, C., Bredt, D.S., Nicoll, R.A. Nat. Neurosci. (2005) [Pubmed]
  8. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. Tomita, S., Chen, L., Kawasaki, Y., Petralia, R.S., Wenthold, R.J., Nicoll, R.A., Bredt, D.S. J. Cell Biol. (2003) [Pubmed]
  9. A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. De Gendt, K., Swinnen, J.V., Saunders, P.T., Schoonjans, L., Dewerchin, M., Devos, A., Tan, K., Atanassova, N., Claessens, F., Lécureuil, C., Heyns, W., Carmeliet, P., Guillou, F., Sharpe, R.M., Verhoeven, G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Vesicular stomatitis virus antigenic octapeptide N52-59 is anchored into the groove of the H-2Kb molecule by the side chains of three amino acids and the main-chain atoms of the amino terminus. Shibata, K., Imarai, M., van Bleek, G.M., Joyce, S., Nathenson, S.G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  11. Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse. Henshall, S.M., Afar, D.E., Hiller, J., Horvath, L.G., Quinn, D.I., Rasiah, K.K., Gish, K., Willhite, D., Kench, J.G., Gardiner-Garden, M., Stricker, P.D., Scher, H.I., Grygiel, J.J., Agus, D.B., Mack, D.H., Sutherland, R.L. Cancer Res. (2003) [Pubmed]
  12. Isolation of an androgen-inducible novel lipocalin gene, Arg1, from androgen-dependent mouse mammary Shionogi carcinoma cells. Kobayashi, M., Kinouchi, T., Hakamata, Y., Kamiakito, T., Kuriki, K., Suzuki, K., Tokue, A., Fukayama, M., Tanaka, A. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  13. DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs. Elliott, R.W., Berger, F.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  14. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Jin, R.J., Wang, Y., Masumori, N., Ishii, K., Tsukamoto, T., Shappell, S.B., Hayward, S.W., Kasper, S., Matusik, R.J. Cancer Res. (2004) [Pubmed]
  15. Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Kim, T.S., Heinlein, C., Hackman, R.C., Nelson, P.S. Mol. Cell. Biol. (2006) [Pubmed]
  16. Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cells. Heitzer, M.D., DeFranco, D.B. Cancer Res. (2006) [Pubmed]
  17. A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice. Lareyre, J.J., Thomas, T.Z., Zheng, W.L., Kasper, S., Ong, D.E., Orgebin-Crist, M.C., Matusik, R.J. J. Biol. Chem. (1999) [Pubmed]
  18. Identification of a functional androgen response element in the promoter of the gene for the androgen-regulated aldose reductase-like protein specific to the mouse vas deferens. Fabre, S., Manin, M., Pailhoux, E., Veyssière, G., Jean, C. J. Biol. Chem. (1994) [Pubmed]
  19. Androgen-regulated ornithine decarboxylase mRNAs of mouse kidney. Berger, F.G., Szymanski, P., Read, E., Watson, G. J. Biol. Chem. (1984) [Pubmed]
  20. Response elements of the androgen-regulated C3 gene. Tan, J.A., Marschke, K.B., Ho, K.C., Perry, S.T., Wilson, E.M., French, F.S. J. Biol. Chem. (1992) [Pubmed]
  21. Differential expression of the mouse mitochondrial genes and the mitochondrial RNA-processing endoribonuclease RNA by androgens. Cornwall, G.A., Orgebin-Crist, M.C., Hann, S.R. Mol. Endocrinol. (1992) [Pubmed]
  22. Combination antiangiogenic and androgen deprivation therapy for prostate cancer: a promising therapeutic approach. Nicholson, B., Gulding, K., Conaway, M., Wedge, S.R., Theodorescu, D. Clin. Cancer Res. (2004) [Pubmed]
  23. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney. Isern, J., Hagenbuch, B., Stieger, B., Meier, P.J., Meseguer, A. Biochim. Biophys. Acta (2001) [Pubmed]
  24. An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta -hydroxylase in adrenocortical cells. Mukai, K., Mitani, F., Nagasawa, H., Suzuki, R., Suzuki, T., Suematsu, M., Ishimura, Y. J. Biol. Chem. (2003) [Pubmed]
  25. Conditional loss of Nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Abdulkadir, S.A., Magee, J.A., Peters, T.J., Kaleem, Z., Naughton, C.K., Humphrey, P.A., Milbrandt, J. Mol. Cell. Biol. (2002) [Pubmed]
  26. The 5'-flanking region of the murine epididymal protein of 17 kilodaltons gene targets transgene expression in the epididymis. Suzuki, K., Araki, Y., Zhu, M.Y., Lareyre, J.J., Matusik, R.J., Orgebin-Crist, M.C. Endocrinology (2003) [Pubmed]
  27. Localization of the transglutaminase cross-linking site in SVS III, a novel glycoprotein secreted from mouse seminal vesicle. Lin, H.J., Luo, C.W., Chen, Y.H. J. Biol. Chem. (2002) [Pubmed]
  28. The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Denolet, E., De Gendt, K., Allemeersch, J., Engelen, K., Marchal, K., Van Hummelen, P., Tan, K.A., Sharpe, R.M., Saunders, P.T., Swinnen, J.V., Verhoeven, G. Mol. Endocrinol. (2006) [Pubmed]
  29. The role of forkhead box A2 to restrict androgen-regulated gene expression of lipocalin 5 in the mouse epididymis. Yu, X., Suzuki, K., Wang, Y., Gupta, A., Jin, R., Orgebin-Crist, M.C., Matusik, R. Mol. Endocrinol. (2006) [Pubmed]
  30. Androgen regulated expression of a spermine binding protein gene in mouse ventral prostate. Mills, J.S., Needham, M., Parker, M.G. Nucleic Acids Res. (1987) [Pubmed]
  31. Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Jeong, B.C., Hong, C.Y., Chattopadhyay, S., Park, J.H., Gong, E.Y., Kim, H.J., Chun, S.Y., Lee, K. Mol. Endocrinol. (2004) [Pubmed]
  32. Androgen receptor up-regulates insulin-like growth factor binding protein-5 (IGFBP-5) expression in a human prostate cancer xenograft. Gregory, C.W., Kim, D., Ye, P., D'Ercole, A.J., Pretlow, T.G., Mohler, J.L., French, F.S. Endocrinology (1999) [Pubmed]
  33. Identification of androgen-regulated genes in mouse kidney by representational difference analysis and random arbitrarily primed polymerase chain reaction. Melià, M.J., Bofill, N., Hubank, M., Meseguer, A. Endocrinology (1998) [Pubmed]
  34. Time-dependent rescue of gene expression by androgens in the mouse proximal caput epididymidis-1 cell line after androgen withdrawal. Seenundun, S., Robaire, B. Endocrinology (2007) [Pubmed]
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