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Sox13  -  SRY (sex determining region Y)-box 13

Mus musculus

Synonyms: AA407916, AW259412, AW540933, SRY (Sex determining region Y)-box 13, Sox-13, ...
 
 
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High impact information on Sox13

  • Sox13 and L-Sox5 showed expression in most of the pancreatic epithelial cells between embryonic days 12.5 and 14 [1].
  • Here we describe the temporal and spatial expression of SOX13 protein during mouse organogenesis [2].
  • We show here that SOX13 is expressed in the developing mouse brain and spinal cord from E12.5 to E15.5, where it is largely confined to the differentiating zone rather than to the proliferating zone [3].
  • Our data suggest a role for SOX13 in the specification and/or differentiation of a specific subset of neurons in the developing central nervous system [3].
  • In particular, we found that SOX13 expression was activated in a subset of neural progenitors as they exit the cycle of mitosis, migrate away from the ventricular zone, and start to differentiate into neurons [3].
 

Anatomical context of Sox13

References

  1. Expression of Sox transcription factors in the developing mouse pancreas. Lioubinski, O., Müller, M., Wegner, M., Sander, M. Dev. Dyn. (2003) [Pubmed]
  2. SOX13 Exhibits a Distinct Spatial and Temporal Expression Pattern During Chondrogenesis, Neurogenesis, and Limb Development. Wang, Y., Ristevski, S., Harley, V.R. J. Histochem. Cytochem. (2006) [Pubmed]
  3. SOX13 is up-regulated in the developing mouse neuroepithelium and identifies a sub-population of differentiating neurons. Wang, Y., Bagheri-Fam, S., Harley, V.R. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  4. Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Melichar, H.J., Narayan, K., Der, S.D., Hiraoka, Y., Gardiol, N., Jeannet, G., Held, W., Chambers, C.A., Kang, J. Science (2007) [Pubmed]
 
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