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Gene Review

SOX13  -  SRY (sex determining region Y)-box 13

Homo sapiens

Synonyms: ICA12, Islet cell antigen 12, MGC117216, SRY (Sex determining region Y)-box 13, Sox-13, ...
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Disease relevance of SOX13


High impact information on SOX13


Biological context of SOX13


Anatomical context of SOX13

  • SOX13 is expressed in the developing central nervous system including the neural tube and the developing brain [7].
  • SOX13 is also detected in the developing kidney, pancreas, and liver as well as in the visceral mesoderm of the extra-embryonic yolk sac and spongiotrophoblast layer of the placenta [7].
  • Antibodies were measured by radioimmunoprecipitation (RIP) using (35) S labelled SOX13 expressed in rabbit reticulocyte lysate [9].
  • Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13 [10].
  • Low level expression was observed in the inner ear of 13.5 dpc mice and in a limited number of cells in the thymus of 16.5 dpc mice, from which Sox-13 was originally cloned [11].

Associations of SOX13 with chemical compounds

  • Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA), tyrosine phosphatase antibodies (IA-2A), and antibodies against the transcription factor SOX13 (SOX13Ab) were analyzed with radioimmunoprecipitating assays [12].

Other interactions of SOX13

  • Anti-SOX13 usually occurred with anti-GAD but rarely with anti-ICA512 [9].
  • Antibodies (Abs) to tyrosine pyrophosphatase (IA2-Abs), glutamate decarboxylase 65 (GAD65-Abs), and other minor markers like ICA12 Abs and tissue transglutaminase Abs (TTG-Abs) were studied [13].
  • Of the MMDM patients 30% were positive for either GAD65 or IA-2 antibodies, and 14% were positive for ICA12 antibodies [13].

Analytical, diagnostic and therapeutic context of SOX13


  1. Autoantibodies to the transcriptional factor SOX13 in primary biliary cirrhosis compared with other diseases. Fida, S., Myers, M.A., Whittingham, S., Rowley, M.J., Ozaki, S., Mackay, I.R. J. Autoimmun. (2002) [Pubmed]
  2. SOX13 autoantibodies are likely to be a supplementary marker for type 1 diabetes in Korea. Park, Y., Park, H., Yoo, E., Kim, D. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  3. Autoantibodies to ICA12 (SOX-13) are not specific for Type I diabetes. Steinbrenner, H., Lohmann, T., Ostendorf, B., Scherbaum, W.A., Seissler, J. Diabetologia (2000) [Pubmed]
  4. Antibodies to new beta cell antigen ICA12 in Latvian diabetes patients. Shtauvere-Brameus, A., Hagopian, W., Rumba, I., Sanjeevi, C.B. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  5. Sex-determining region Y-related protein SOX13 is a diabetes autoantigen expressed in pancreatic islets. Kasimiotis, H., Myers, M.A., Argentaro, A., Mertin, S., Fida, S., Ferraro, T., Olsson, J., Rowley, M.J., Harley, V.R. Diabetes (2000) [Pubmed]
  6. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Roose, J., Korver, W., de Boer, R., Kuipers, J., Hurenkamp, J., Clevers, H. Genomics (1999) [Pubmed]
  7. SOX13 Exhibits a Distinct Spatial and Temporal Expression Pattern During Chondrogenesis, Neurogenesis, and Limb Development. Wang, Y., Ristevski, S., Harley, V.R. J. Histochem. Cytochem. (2006) [Pubmed]
  8. Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes. Argentaro, A., Wapelhorst, B., Concannon, P., Harley, V.R. Mol. Genet. Metab. (2001) [Pubmed]
  9. Antibodies to SOX13 (ICA12) are associated with type 1 diabetes. Kasimiotis, H., Fida, S., Rowley, M.J., Mackay, I.R., Zimmet, P.Z., Gleason, S., Rabin, D.U., Myers, M.A. Autoimmunity (2001) [Pubmed]
  10. Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13. Melichar, H.J., Narayan, K., Der, S.D., Hiraoka, Y., Gardiol, N., Jeannet, G., Held, W., Chambers, C.A., Kang, J. Science (2007) [Pubmed]
  11. High expression of the HMG box factor sox-13 in arterial walls during embryonic development. Roose, J., Korver, W., Oving, E., Wilson, A., Wagenaar, G., Markman, M., Lamers, W., Clevers, H. Nucleic Acids Res. (1998) [Pubmed]
  12. Increased autoantibodies to SOX13 in Swedish patients with type 1 diabetes. Törn, C., Shtauvere-Brameus, A., Sanjeevi, C.B., Landin-Olsson, M. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  13. Molecular mechanisms involved in the etiopathogenesis of malnutrition-modulated diabetes mellitus. Kanungo, A., Samal, K.C., Sanjeevi, C.B. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  14. Genomic characterisation and fine mapping of the human SOX13 gene. Argentaro, A., Olsson, J., Critcher, R., McDowall, S.G., Harley, V.R. Gene (2000) [Pubmed]
  15. Antibodies to diabetes-associated autoantigens in Indian patients with Type 1 diabetes: prevalence of anti-ICA512/IA2 and anti-SOX13. Fida, S., Myers, M., Mackay, I.R., Zimmet, P.Z., Mohan, V., Deepa, R., Rowley, M.J. Diabetes Res. Clin. Pract. (2001) [Pubmed]
  16. Cloning and expression of IDDM-specific human autoantigens. Rabin, D.U., Pleasic, S.M., Palmer-Crocker, R., Shapiro, J.A. Diabetes (1992) [Pubmed]
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