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Gene Review

Sox5  -  SRY (sex determining region Y)-box 5

Mus musculus

Synonyms: A730017D01Rik, AI528773, Sox-5, Transcription factor SOX-5
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High impact information on Sox5


Biological context of Sox5

  • In common with Sox5, Sox6 is highly expressed in the adult mouse testis and the HMG domains of both proteins bind to the sequence 5'-AACAAT-3'. This suggests that the two genes may have overlapping functions in the regulation of gene expression during spermatogenesis in the adult mouse [4].
  • SOX5 cDNAs isolated from a human adult testis cDNA library show a high similarity with the mouse Sox5 transcript over a large region identical in all the human cDNAs [5].
  • L-Sox5 and Sox6 are thus redundant, potent enhancers of chondroblast functions, thereby essential for endochondral skeleton formation [6].
  • Sox-5 is a DNA binding protein and binding site selection assays suggest that it can bind specifically to oligonucleotides containing the consensus motif AACAAT [3].
  • Sox-5 is one of a family of genes which show homology to the HMG box region of the testis determining gene SRY [7].

Anatomical context of Sox5

  • Sox13 and L-Sox5 showed expression in most of the pancreatic epithelial cells between embryonic days 12.5 and 14 [8].
  • Sox5 and Sox6 promote the development of a highly proliferating pool of chondroblasts between the epiphyses and metaphyses of future long bones [2].
  • In conclusion, Sox5 and Sox6 are needed for the establishment of multilayered growth plates, and thereby for proper and timely development of endochondral bones [2].
  • Our analysis of Sox5/Sox6 double mutants, in which the chondroprogenitors are unable to differentiate into cartilage, reveals that the two cell fates arising from the sclerotome, axial tendon and cartilage are alternative lineages, and that cartilage differentiation is required to actively repress tendon development in the dorsolateral sclerotome [9].
  • Sox5 and Sox6 which are expressed in post-meiotic germ cells bound TSBR4 [10].

Associations of Sox5 with chemical compounds

  • This identified (i) an additional 91 amino acids upstream of the previously designated methionine start codon in the original cDNA, and (ii) an intron encoded within the HMG box/DNA binding domain in exactly the same position as that found in the Sox5, -13 and -17 genes [11].

Other interactions of Sox5

  • DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5 [7].
  • In contrast, overexpression of another Sox member, Sox5, triggered no such trans-activation of mor DP-driven luciferase activity or DNA-protein binding activity [12].
  • The HMG domain is encoded by exons XI and XII, separated by an intron that is conserved among Sox-5, Sox-13, and Sox-17 [13].
  • These results suggest that reduced expression of Osterix in combination with Sox9-Sox5 expression is important for the onset of condylar (secondary) cartilage formation [14].
  • The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box [15].

Analytical, diagnostic and therapeutic context of Sox5


  1. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Akiyama, H., Chaboissier, M.C., Martin, J.F., Schedl, A., de Crombrugghe, B. Genes Dev. (2002) [Pubmed]
  2. Sox5 and Sox6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate. Smits, P., Dy, P., Mitra, S., Lefebvre, V. J. Cell Biol. (2004) [Pubmed]
  3. An SRY-related gene expressed during spermatogenesis in the mouse encodes a sequence-specific DNA-binding protein. Denny, P., Swift, S., Connor, F., Ashworth, A. EMBO J. (1992) [Pubmed]
  4. The Sry-related HMG box-containing gene Sox6 is expressed in the adult testis and developing nervous system of the mouse. Connor, F., Wright, E., Denny, P., Koopman, P., Ashworth, A. Nucleic Acids Res. (1995) [Pubmed]
  5. Cloning and characterization of SOX5, a new member of the human SOX gene family. Wunderle, V.M., Critcher, R., Ashworth, A., Goodfellow, P.N. Genomics (1996) [Pubmed]
  6. The transcription factors L-Sox5 and Sox6 are essential for cartilage formation. Smits, P., Li, P., Mandel, J., Zhang, Z., Deng, J.M., Behringer, R.R., de Crombrugghe, B., Lefebvre, V. Dev. Cell (2001) [Pubmed]
  7. DNA binding and bending properties of the post-meiotically expressed Sry-related protein Sox-5. Connor, F., Cary, P.D., Read, C.M., Preston, N.S., Driscoll, P.C., Denny, P., Crane-Robinson, C., Ashworth, A. Nucleic Acids Res. (1994) [Pubmed]
  8. Expression of Sox transcription factors in the developing mouse pancreas. Lioubinski, O., Müller, M., Wegner, M., Sander, M. Dev. Dyn. (2003) [Pubmed]
  9. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Brent, A.E., Braun, T., Tabin, C.J. Development (2005) [Pubmed]
  10. Testis expression of hormone-sensitive lipase is conferred by a specific promoter that contains four regions binding testicular nuclear proteins. Blaise, R., Grober, J., Rouet, P., Tavernier, G., Daegelen, D., Langin, D. J. Biol. Chem. (1999) [Pubmed]
  11. Cloning and functional analysis of the Sry-related HMG box gene, Sox18. Hosking, B.M., Wyeth, J.R., Pennisi, D.J., Wang, S.C., Koopman, P., Muscat, G.E. Gene (2001) [Pubmed]
  12. Transcriptional modulation of mouse mu-opioid receptor distal promoter activity by Sox18. Im, H.J., Smirnov, D., Yuhi, T., Raghavan, S., Olsson, J.E., Muscat, G.E., Koopman, P., Loh, H.H. Mol. Pharmacol. (2001) [Pubmed]
  13. The Sox-13 gene: structure, promoter characterization, and chromosomal localization. Roose, J., Korver, W., de Boer, R., Kuipers, J., Hurenkamp, J., Clevers, H. Genomics (1999) [Pubmed]
  14. An in situ hybridization study of Runx2, Osterix, and Sox9 at the onset of condylar cartilage formation in fetal mouse mandible. Shibata, S., Suda, N., Suzuki, S., Fukuoka, H., Yamashita, Y. J. Anat. (2006) [Pubmed]
  15. The mouse Sox5 gene encodes a protein containing the leucine zipper and the Q box. Hiraoka, Y., Ogawa, M., Sakai, Y., Kido, S., Aiso, S. Biochim. Biophys. Acta (1998) [Pubmed]
  16. The energetics of HMG box interactions with DNA: thermodynamic description of the target DNA duplexes. Jelesarov, I., Crane-Robinson, C., Privalov, P.L. J. Mol. Biol. (1999) [Pubmed]
  17. The energetics of HMG box interactions with DNA: thermodynamics of the DNA binding of the HMG box from mouse sox-5. Privalov, P.L., Jelesarov, I., Read, C.M., Dragan, A.I., Crane-Robinson, C. J. Mol. Biol. (1999) [Pubmed]
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