Gene Review:
Etnk2 - ethanolamine kinase 2
Mus musculus
Synonyms:
4933417N20Rik, AI197444, EKI 2, Eki2, Ethanolamine kinase 2, ...
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Disease relevance of Etnk2
- Histological analysis of pregnant Etnk2(-/-) females showed that fetal development failed at the late stage of pregnancy in a significant percentage of embryos because of the appearance of extensive placental thrombosis [1].
- The Etnk2(-/-) mice exhibited a maternal-specific intrauterine growth retardation phenotype that resulted in a 33% reduction in litter size and frequent perinatal death [1].
- Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2 [1].
High impact information on Etnk2
- In this work, the predicted Etnk2 cDNA was established as a soluble protein with ethanolamine-specific kinase activity that was most highly expressed in liver [1].
- PtdEtn is a major precursor to phosphatidylcholine in liver; however, Etnk2(-/-) mice did not have reduced amounts of either PtdEtn or phosphatidylcholine or an altered phospholipid molecular species distribution [1].
- Mice with an inactivated Etnk2 gene were derived, and its absence reduced the rate of PtdEtn synthesis from exogenous ethanolamine in hepatocytes [1].
References
- Placental thrombosis and spontaneous fetal death in mice deficient in ethanolamine kinase 2. Tian, Y., Jackson, P., Gunter, C., Wang, J., Rock, C.O., Jackowski, S. J. Biol. Chem. (2006) [Pubmed]
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