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Gene Review

Cdc73  -  cell division cycle 73, Paf1/RNA...

Mus musculus

Synonyms: 8430414L16Rik, BC027756, C130030P16Rik, C81219, Cell division cycle protein 73 homolog, ...
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Disease relevance of Cdc73

  • Parafibromin is a protein encoded by the HRPT2 oncosuppressor gene, whose mutation causes the hyperparathyroidism-jaw tumour syndrome, characterized by the occurrence of parathyroid adenoma or carcinoma, fibro-osseous jaw tumours, and renal neoplastic and non-neoplastic abnormalities [1].

High impact information on Cdc73


Analytical, diagnostic and therapeutic context of Cdc73

  • Non-morphological techniques, such as Northern and Western blotting and reverse transcriptase-PCR, indicate that parafibromin is ubiquitously expressed, but extensive immunohistochemical studies have not been performed [1].
  • To increase our knowledge of the distribution and patterns of expression of parafibromin, we examined its expression and location in many different mouse and human organs by immunohistochemistry [1].


  1. Immunohistochemical assessment of parafibromin in mouse and human tissues. Porzionato, A., Macchi, V., Barzon, L., Masi, G., Iacobone, M., Parenti, A., Pal??, G., De Caro, R. J. Anat. (2006) [Pubmed]
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