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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Aldh5a1  -  aldhehyde dehydrogenase family 5,...

Mus musculus

Synonyms: 6330403E24Rik, Ahd-1, Ahd1, Aldehyde dehydrogenase family 5 member A1, D630032B01Rik, ...
 
 
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Disease relevance of Aldh5a1

 

High impact information on Aldh5a1

  • Indeed, treatment of mutant mice with the amino acid taurine rescued Aldh5a1-/- mice [1].
 

Analytical, diagnostic and therapeutic context of Aldh5a1

  • The membrane homogenate binding and quantitative autoradiography using [(3)H]NCS-382 revealed no significant changes in the affinity (K(d)), receptor density (B(max)), or displacement potency (IC(50)) in various brain regions of Aldh5a1(-/-) vs. Aldh5a1(+/+) mice [2].

References

  1. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Hogema, B.M., Gupta, M., Senephansiri, H., Burlingame, T.G., Taylor, M., Jakobs, C., Schutgens, R.B., Froestl, W., Snead, O.C., Diaz-Arrastia, R., Bottiglieri, T., Grompe, M., Gibson, K.M. Nat. Genet. (2001) [Pubmed]
  2. Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain. Mehta, A.K., Gould, G.G., Gupta, M., Carter, L.P., Gibson, K.M., Ticku, M.K. Mol. Genet. Metab. (2006) [Pubmed]
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