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Gene Review

Aldh5a1  -  aldehyde dehydrogenase 5 family, member A1

Rattus norvegicus

Synonyms: Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, Ssadh, Succinate-semialdehyde dehydrogenase, mitochondrial
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Anatomical context of Aldh5a1


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Analytical, diagnostic and therapeutic context of Aldh5a1

  • Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression [13].


  1. Biochemical and molecular characterization of a succinate semialdehyde dehydrogenase involved in the catabolism of 4-hydroxybutyric acid in Ralstonia eutropha. Lütke-Eversloh, T., Steinbüchel, A. FEMS Microbiol. Lett. (1999) [Pubmed]
  2. Aminobutyrate aminotransferase and succinate semialdehyde dehydrogenase in regions of rat brain after insulin-induced hypoglycemia. Gupta, K.P., Baquer, N.Z. Indian J. Biochem. Biophys. (1984) [Pubmed]
  3. Oxidation of 4-hydroxy-2-nonenal by succinic semialdehyde dehydrogenase (ALDH5A). Murphy, T.C., Amarnath, V., Gibson, K.M., Picklo, M.J. J. Neurochem. (2003) [Pubmed]
  4. Studies on analogues of succinic semialdehyde as substrates for succinate semialdehyde dehydrogenase from rat brain. Manzocchi, A., Biondi, P., Secchi, C., Santaniello, E. J. Neurochem. (1986) [Pubmed]
  5. Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. Nguyen, E., Picklo, M.J. Biochim. Biophys. Acta (2003) [Pubmed]
  6. Studies on the control of 4-aminobutyrate metabolism in 'synaptosomal' and free rat brain mitochondria. Walsh, J.M., Clark, J.B. Biochem. J. (1976) [Pubmed]
  7. Electron-cytochemical localization of succinic semialdehyde dehydrogenase activity in Purkinje neurons and hepatocytes of the rat. Bernocchi, G., Barni, S., Biggiogera, M. J. Neurosci. Methods (1986) [Pubmed]
  8. Histochemical patterns of succinic semialdehyde dehydrogenase activity within the Purkinje cell population during rat cerebellar histogenesis. Bernocchi, G., Scherini, E. Acta Histochem. (1983) [Pubmed]
  9. Aldehyde dehydrogenases in rat brain. Subcellular distribution and properties. Pettersson, H., Tottmar, O. J. Neurochem. (1982) [Pubmed]
  10. Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Hellström, E., Tottmar, O. Biochem. Pharmacol. (1982) [Pubmed]
  11. Methodological problems in the histochemical demonstration of succinate semialdehyde dehydrogenase activity. Bernocchi, G., Barni, S. Histochem. J. (1983) [Pubmed]
  12. Differential effects of GABA analogues and zinc on glutamate decarboxylase, 4-aminobutyric-2-oxoglutaric acid transaminase and succinate semialdehyde dehydrogenase in rat brain tissue. de Boer, T., Bruinvels, J., Bonta, I.L. J. Neurochem. (1979) [Pubmed]
  13. Molecular cloning of the mature NAD(+)-dependent succinic semialdehyde dehydrogenase from rat and human. cDNA isolation, evolutionary homology, and tissue expression. Chambliss, K.L., Caudle, D.L., Hinson, D.D., Moomaw, C.R., Slaughter, C.A., Jakobs, C., Gibson, K.M. J. Biol. Chem. (1995) [Pubmed]
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