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Gene Review

Eea1  -  early endosome antigen 1

Mus musculus

Synonyms: A430109M19Rik, B230358H09Rik, Early endosome antigen 1, ZFYVE2
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High impact information on Eea1


Biological context of Eea1

  • EC-SOD also colocalized with early endosome antigen 1 (EEA-1), a specific marker for endocytosis [5].


  1. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Richardson, S.C., Winistorfer, S.C., Poupon, V., Luzio, J.P., Piper, R.C. Mol. Biol. Cell (2004) [Pubmed]
  2. The FYVE domain of early endosome antigen 1 is required for both phosphatidylinositol 3-phosphate and Rab5 binding. Critical role of this dual interaction for endosomal localization. Lawe, D.C., Patki, V., Heller-Harrison, R., Lambright, D., Corvera, S. J. Biol. Chem. (2000) [Pubmed]
  3. Mouse polyomavirus enters early endosomes, requires their acidic pH for productive infection, and meets transferrin cargo in Rab11-positive endosomes. Liebl, D., Difato, F., Horníková, L., Mannová, P., Stokrová, J., Forstová, J. J. Virol. (2006) [Pubmed]
  4. Maturation of Rhodococcus equi-containing vacuoles is arrested after completion of the early endosome stage. Fernandez-Mora, E., Polidori, M., Lührmann, A., Schaible, U.E., Haas, A. Traffic (2005) [Pubmed]
  5. Endocytosis of extracellular superoxide dismutase into endothelial cells: role of the heparin-binding domain. Chu, Y., Piper, R., Richardson, S., Watanabe, Y., Patel, P., Heistad, D.D. Arterioscler. Thromb. Vasc. Biol. (2006) [Pubmed]
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