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Gene Review

Cav1  -  caveolin 1, caveolae protein

Mus musculus

Synonyms: Cav, Cav-1, Caveolin-1, caveolin-1
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Disease relevance of Cav1


Psychiatry related information on Cav1


High impact information on Cav1

  • Caveolin-1, the primary coat protein of caveolae, has been implicated as a regulator of signal transduction through binding of its "scaffolding domain" to key signaling molecules [7].
  • However, the physiological importance of caveolin-1 in regulating signaling has been difficult to distinguish from its traditional functions in caveolae assembly, transcytosis, and cholesterol transport [7].
  • Upon phosphorylation of Cbl, the CAP-Cbl complex dissociates from the insulin receptor and moves to a caveolin-enriched, triton-insoluble membrane fraction [8].
  • These data imply that the caveolin-1 scaffolding domain can selectively regulate signal transduction to eNOS in endothelial cells and that small-molecule mimicry of this domain may provide a new therapeutic approach [7].
  • Pterin binding refolds the central interface region, recruits new structural elements, creates a 30 angstrom deep active-center channel, and causes a 35 degrees helical tilt to expose a heme edge and the adjacent residue tryptophan-366 for likely reductase domain interactions and caveolin inhibition [9].

Chemical compound and disease context of Cav1


Biological context of Cav1


Anatomical context of Cav1


Associations of Cav1 with chemical compounds


Physical interactions of Cav1


Enzymatic interactions of Cav1


Co-localisations of Cav1

  • Finally, we have observed that after IGF-I stimulation, IGF-IR and Fyn colocalize in lipid raft caveolin 1-enriched microdomains [29].

Regulatory relationships of Cav1


Other interactions of Cav1


Analytical, diagnostic and therapeutic context of Cav1


  1. Disruption of the caveolin-1 gene impairs renal calcium reabsorption and leads to hypercalciuria and urolithiasis. Cao, G., Yang, G., Timme, T.L., Saika, T., Truong, L.D., Satoh, T., Goltsov, A., Park, S.H., Men, T., Kusaka, N., Tian, W., Ren, C., Wang, H., Kadmon, D., Cai, W.W., Chinault, A.C., Boone, T.B., Bradley, A., Thompson, T.C. Am. J. Pathol. (2003) [Pubmed]
  2. Oxidative Stress Induces Premature Senescence by Stimulating Caveolin-1 Gene Transcription through p38 Mitogen-Activated Protein Kinase/Sp1-Mediated Activation of Two GC-Rich Promoter Elements. Dasari, A., Bartholomew, J.N., Volonte, D., Galbiati, F. Cancer Res. (2006) [Pubmed]
  3. Caveolin-1/3 double-knockout mice are viable, but lack both muscle and non-muscle caveolae, and develop a severe cardiomyopathic phenotype. Park, D.S., Woodman, S.E., Schubert, W., Cohen, A.W., Frank, P.G., Chandra, M., Shirani, J., Razani, B., Tang, B., Jelicks, L.A., Factor, S.M., Weiss, L.M., Tanowitz, H.B., Lisanti, M.P. Am. J. Pathol. (2002) [Pubmed]
  4. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. Murata, T., Lin, M.I., Huang, Y., Yu, J., Bauer, P.M., Giordano, F.J., Sessa, W.C. J. Exp. Med. (2007) [Pubmed]
  5. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. Volonte, D., Kahkonen, B., Shapiro, S., Di, Y., Galbiati, F. J. Biol. Chem. (2009) [Pubmed]
  6. Increased caveolin-1 expression in Alzheimer's disease brain. Gaudreault, S.B., Dea, D., Poirier, J. Neurobiol. Aging (2004) [Pubmed]
  7. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Bucci, M., Gratton, J.P., Rudic, R.D., Acevedo, L., Roviezzo, F., Cirino, G., Sessa, W.C. Nat. Med. (2000) [Pubmed]
  8. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Baumann, C.A., Ribon, V., Kanzaki, M., Thurmond, D.C., Mora, S., Shigematsu, S., Bickel, P.E., Pessin, J.E., Saltiel, A.R. Nature (2000) [Pubmed]
  9. Structure of nitric oxide synthase oxygenase dimer with pterin and substrate. Crane, B.R., Arvai, A.S., Ghosh, D.K., Wu, C., Getzoff, E.D., Stuehr, D.J., Tainer, J.A. Science (1998) [Pubmed]
  10. Altered expression of caveolin-1 and increased cholesterol in detergent insoluble membrane fractions from liver in mice with Niemann-Pick disease type C. Garver, W.S., Erickson, R.P., Wilson, J.M., Colton, T.L., Hossain, G.S., Kozloski, M.A., Heidenreich, R.A. Biochim. Biophys. Acta (1997) [Pubmed]
  11. Caveolin-1 Regulates NF-{kappa}B Activation and Lung Inflammatory Response to Sepsis Induced by Lipopolysaccharide. Garrean, S., Gao, X.P., Brovkovych, V., Shimizu, J., Zhao, Y.Y., Vogel, S.M., Malik, A.B. J. Immunol. (2006) [Pubmed]
  12. Caveolin-1 mutations in human breast cancer: functional association with estrogen receptor alpha-positive status. Li, T., Sotgia, F., Vuolo, M.A., Li, M., Yang, W.C., Pestell, R.G., Sparano, J.A., Lisanti, M.P. Am. J. Pathol. (2006) [Pubmed]
  13. Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation. Salatino, M., Beguelin, W., Peters, M.G., Carnevale, R., Proietti, C.J., Galigniana, M.D., Vedoy, C.G., Schillaci, R., Charreau, E.H., Sogayar, M.C., Elizalde, P.V. Oncogene (2006) [Pubmed]
  14. Caveolin-1 deficiency stimulates neointima formation during vascular injury. Hassan, G.S., Jasmin, J.F., Schubert, W., Frank, P.G., Lisanti, M.P. Biochemistry (2004) [Pubmed]
  15. The adipocyte plasma membrane caveolin functional/structural organization is necessary for the efficient endocytosis of GLUT4. Shigematsu, S., Watson, R.T., Khan, A.H., Pessin, J.E. J. Biol. Chem. (2003) [Pubmed]
  16. Caveolin-1 is not required for murine intestinal cholesterol transport. Valasek, M.A., Weng, J., Shaul, P.W., Anderson, R.G., Repa, J.J. J. Biol. Chem. (2005) [Pubmed]
  17. Loss of caveolin-1 expression is associated with disruption of muscarinic cholinergic activities in the urinary bladder. Lai, H.H., Boone, T.B., Yang, G., Smith, C.P., Kiss, S., Thompson, T.C., Somogyi, G.T. Neurochem. Int. (2004) [Pubmed]
  18. cAbl tyrosine kinase mediates reactive oxygen species- and caveolin-dependent AT1 receptor signaling in vascular smooth muscle: role in vascular hypertrophy. Ushio-Fukai, M., Zuo, L., Ikeda, S., Tojo, T., Patrushev, N.A., Alexander, R.W. Circ. Res. (2005) [Pubmed]
  19. Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles. El-Yazbi, A.F., Cho, W.J., Boddy, G., Schulz, R., Daniel, E.E. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  20. Colocalization between caveolin isoforms in the intestinal smooth muscle and interstitial cells of Cajal of the Cav1(+/+) and Cav1 (-/-) mouse. Cho, W.J., Daniel, E.E. Histochem. Cell Biol. (2006) [Pubmed]
  21. Insulin resistance in skeletal muscles of caveolin-3-null mice. Oshikawa, J., Otsu, K., Toya, Y., Tsunematsu, T., Hankins, R., Kawabe, J., Minamisawa, S., Umemura, S., Hagiwara, Y., Ishikawa, Y. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Intracellular retention of glycosylphosphatidyl inositol-linked proteins in caveolin-deficient cells. Sotgia, F., Razani, B., Bonuccelli, G., Schubert, W., Battista, M., Lee, H., Capozza, F., Schubert, A.L., Minetti, C., Buckley, J.T., Lisanti, M.P. Mol. Cell. Biol. (2002) [Pubmed]
  23. Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction. Huo, H., Guo, X., Hong, S., Jiang, M., Liu, X., Liao, K. J. Biol. Chem. (2003) [Pubmed]
  24. Cholesteryl ester is transported from caveolae to internal membranes as part of a caveolin-annexin II lipid-protein complex. Uittenbogaard, A., Everson, W.V., Matveev, S.V., Smart, E.J. J. Biol. Chem. (2002) [Pubmed]
  25. Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. Kim, Y.N., Wiepz, G.J., Guadarrama, A.G., Bertics, P.J. J. Biol. Chem. (2000) [Pubmed]
  26. Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Razandi, M., Alton, G., Pedram, A., Ghonshani, S., Webb, P., Levin, E.R. Mol. Cell. Biol. (2003) [Pubmed]
  27. Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Park, D.S., Lee, H., Frank, P.G., Razani, B., Nguyen, A.V., Parlow, A.F., Russell, R.G., Hulit, J., Pestell, R.G., Lisanti, M.P. Mol. Biol. Cell (2002) [Pubmed]
  28. Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and paxillin. Cao, H., Sanguinetti, A.R., Mastick, C.C. Exp. Cell Res. (2004) [Pubmed]
  29. Specificity of insulin-like growth factor I and insulin on Shc phosphorylation and Grb2 recruitment in caveolae. Biedi, C., Panetta, D., Segat, D., Cordera, R., Maggi, D. Endocrinology (2003) [Pubmed]
  30. Prion replication alters the distribution of synaptophysin and caveolin 1 in neuronal lipid rafts. Russelakis-Carneiro, M., Hetz, C., Maundrell, K., Soto, C. Am. J. Pathol. (2004) [Pubmed]
  31. Caveolin-1-deficient aortic smooth muscle cells show cell autonomous abnormalities in proliferation, migration, and endothelin-based signal transduction. Hassan, G.S., Williams, T.M., Frank, P.G., Lisanti, M.P. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  32. IGF-I induces caveolin 1 tyrosine phosphorylation and translocation in the lipid rafts. Maggi, D., Biedi, C., Segat, D., Barbero, D., Panetta, D., Cordera, R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  33. PV-1 is negatively regulated by VEGF in the lung of caveolin-1, but not caveolin-2, null mice. Hnasko, R., Frank, P.G., Ben-Jonathan, N., Lisanti, M.P. Cell Cycle (2006) [Pubmed]
  34. Caveolin-1 up-regulates CD147 glycosylation and the invasive capability of murine hepatocarcinoma cell lines. Jia, L., Wang, S., Zhou, H., Cao, J., Hu, Y., Zhang, J. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  35. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. Le Saux, C.J., Teeters, K., Miyasato, S.K., Hoffmann, P.R., Bollt, O., Douet, V., Shohet, R.V., Broide, D.H., Tam, E.K. J. Biol. Chem. (2008) [Pubmed]
  36. Lung dysfunction causes systemic hypoxia in estrogen receptor beta knockout (ERbeta-/-) mice. Morani, A., Barros, R.P., Imamov, O., Hultenby, K., Arner, A., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  37. Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae. Razani, B., Wang, X.B., Engelman, J.A., Battista, M., Lagaud, G., Zhang, X.L., Kneitz, B., Hou, H., Christ, G.J., Edelmann, W., Lisanti, M.P. Mol. Cell. Biol. (2002) [Pubmed]
  38. Modulation of caveolin-1 expression can affect signalling through the phosphatidylinositol 3-kinase/Akt pathway and cellular proliferation in response to insulin-like growth factor I. Matthews, L.C., Taggart, M.J., Westwood, M. Endocrinology (2008) [Pubmed]
  39. Intracellular retention of caveolin 1 in presenilin-deficient cells. Wood, D.R., Nye, J.S., Lamb, N.J., Fernandez, A., Kitzmann, M. J. Biol. Chem. (2005) [Pubmed]
  40. Molecular cloning and developmental expression of the caveolin gene family in the amphibian Xenopus laevis. Razani, B., Park, D.S., Miyanaga, Y., Ghatpande, A., Cohen, J., Wang, X.B., Scherer, P.E., Evans, T., Lisanti, M.P. Biochemistry (2002) [Pubmed]
  41. Urogenital alterations in aged male caveolin-1 knockout mice. Woodman, S.E., Cheung, M.W., Tarr, M., North, A.C., Schubert, W., Lagaud, G., Marks, C.B., Russell, R.G., Hassan, G.S., Factor, S.M., Christ, G.J., Lisanti, M.P. J. Urol. (2004) [Pubmed]
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