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Trpc5  -  transient receptor potential cation...

Mus musculus

Synonyms: CCE2, Capacitative calcium entry channel 2, Short transient receptor potential channel 5, TRP-5, TRP5, ...
 
 
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High impact information on Trpc5

  • Expression of the TRP5 cDNA, however, did not significantly affect [Ca2+]i transients induced by thapsigargin, an inhibitor of endoplasmic reticulum Ca2+-ATPases [1].
  • Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels [2].
  • Nevertheless, the amino acids in the aromatic cluster I (Trp-5, Tyr-7, Trp-16 and Tyr/Phe-20) have all been conserved, as is the case with the cytoplasmic carbonic anhydrases [3].
  • The replacement of Trp 5 with Phe resulted in a change of peptide's secondary structure and increased binding with MAb and E-selectin, suggesting improved carbohydrate mimicry [4].
  • Possible coupling of prostaglandin E receptor EP(1) to TRP5 expressed in Xenopus laevis oocytes [5].
 

Associations of Trpc5 with chemical compounds

  • Results indicate that Ac-RYYRWK-NH2 behaves as a highly potent and selective partial agonist at the NOP receptors and that the whole indole moiety of the Trp5 side chain is not required, being a phenyl-ethyl side chain already sufficient for maintaining high potency [6].

References

  1. Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. Okada, T., Shimizu, S., Wakamori, M., Maeda, A., Kurosaki, T., Takada, N., Imoto, K., Mori, Y. J. Biol. Chem. (1998) [Pubmed]
  2. Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels. Kanki, H., Kinoshita, M., Akaike, A., Satoh, M., Mori, Y., Kaneko, S. Mol. Pharmacol. (2001) [Pubmed]
  3. Tissue and species distribution of the secreted carbonic anhydrase isoenzyme. Fernley, R.T., Darling, P., Aldred, P., Wright, R.D., Coghlan, J.P. Biochem. J. (1989) [Pubmed]
  4. Role of SA-Le(a) and E-selectin in metastasis assessed with peptide antagonist. O, I., Otvos, L., Kieber-Emmons, T., Blaszczyk-Thurin, M. Peptides (2002) [Pubmed]
  5. Possible coupling of prostaglandin E receptor EP(1) to TRP5 expressed in Xenopus laevis oocytes. Tabata, H., Tanaka, S., Sugimoto, Y., Kanki, H., Kaneko, S., Ichikawa, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2. Carra', G., Calo', G., Spagnolo, B., Guerrini, R., Arduin, M., Marzola, E., Trapella, C., Regoli, D., Salvadori, S. J. Pept. Res. (2005) [Pubmed]
 
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