The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TRPC5  -  transient receptor potential cation...

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of trp

  • The human growth hormone gene sequences have been linked in phase to a fragment of the trp D gene of Escherichia coli in a plasmid vehicle, and a fusion protein is synthesized at high level (approximately 3 percent of bacterial protein) under the control of the regulatory region of the trp operon [1].
  • We find that DT is formed through radical reactions and type I photosensitization (including .OH, O2- and OONO-), but not by 1O2 and NO, (which modify his, trp and met more readily) [2].

High impact information on trp

  • Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells [3].
  • To increase yields of calf prochymosin (PC) produced in Escherichia coli, PC cDNA was cloned in a plasmid vector under control of the trp promoter [4].
  • The DNA coding domains A-B were polymerized one to six times linearly, taking advantage of the non-palindromic nucleotide sequence of the AccI recognition site and the resultant DNAs were inserted in pTRP vector carrying trp promoter [5].
  • The gene encoding chymosin has been cloned and expressed in suitable bacteria and yeast hosts under the control of lac, trp, trp-beta, gly A genes, and serine hydroxymethyl-transferase promoters [6].
  • In E. coli these include vehicles based on the lac operon, the trp operon, the rho leftward operon, and the recA gone; open reading frame cloning vehicles are also discussed, as are steps that can be taken to extrude a gene product from the cell and the use of plasmids with runaway replication [7].

Biological context of trp

  • Another plasmid, pCR701, in which construction of a sequence coding for fMet-PC cDNA that was aided by chemical synthesis, was placed under direct control of the trp promoter, produced PC at a much lower rate [4].

Associations of trp with chemical compounds


  1. Human growth hormone: complementary DNA cloning and expression in bacteria. Martial, J.A., Hallewell, R.A., Baxter, J.D., Goodman, H.M. Science (1979) [Pubmed]
  2. Molecular pathology of dityrosine cross-links in proteins: structural and functional analysis of four proteins. Balasubramanian, D., Kanwar, R. Mol. Cell. Biochem. (2002) [Pubmed]
  3. Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells. Chang, A.S., Chang, S.M., Garcia, R.L., Schilling, W.P. FEBS Lett. (1997) [Pubmed]
  4. Expression of cloned calf prochymosin cDNA under control of the tryptophan promoter. Nishimori, K., Shimizu, N., Kawaguchi, Y., Hidaka, M., Uozumi, T., Beppu, T. Gene (1984) [Pubmed]
  5. Artificial immunoglobulin G-binding protein mimetic to staphylococcal protein A. Its production and application to affinity purification of immunoglobulin G. Kihira, Y., Aiba, S. J. Chromatogr. (1992) [Pubmed]
  6. Bovine chymosin: production by rDNA technology and application in cheese manufacture. Mohanty, A.K., Mukhopadhyay, U.K., Grover, S., Batish, V.K. Biotechnology advances. (1999) [Pubmed]
  7. Expression vehicles used in recombinant DNA technology. Friesen, J.D., An, G. Biotechnology advances. (1983) [Pubmed]
  8. Fluorescence and stopped-flow studies on the N in equilibrium F transition of serumalbumin. Rudolph, R., Holler, E., Jaenicke, R. Biophys. Chem. (1975) [Pubmed]
WikiGenes - Universities