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TRPC5  -  transient receptor potential cation...

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Disease relevance of trp

  • The human growth hormone gene sequences have been linked in phase to a fragment of the trp D gene of Escherichia coli in a plasmid vehicle, and a fusion protein is synthesized at high level (approximately 3 percent of bacterial protein) under the control of the regulatory region of the trp operon [1].
  • We find that DT is formed through radical reactions and type I photosensitization (including .OH, O2- and OONO-), but not by 1O2 and NO, (which modify his, trp and met more readily) [2].
 

High impact information on trp

  • Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells [3].
  • To increase yields of calf prochymosin (PC) produced in Escherichia coli, PC cDNA was cloned in a plasmid vector under control of the trp promoter [4].
  • The DNA coding domains A-B were polymerized one to six times linearly, taking advantage of the non-palindromic nucleotide sequence of the AccI recognition site and the resultant DNAs were inserted in pTRP vector carrying trp promoter [5].
  • The gene encoding chymosin has been cloned and expressed in suitable bacteria and yeast hosts under the control of lac, trp, trp-beta, gly A genes, and serine hydroxymethyl-transferase promoters [6].
  • In E. coli these include vehicles based on the lac operon, the trp operon, the rho leftward operon, and the recA gone; open reading frame cloning vehicles are also discussed, as are steps that can be taken to extrude a gene product from the cell and the use of plasmids with runaway replication [7].
 

Biological context of trp

  • Another plasmid, pCR701, in which construction of a sequence coding for fMet-PC cDNA that was aided by chemical synthesis, was placed under direct control of the trp promoter, produced PC at a much lower rate [4].
 

Associations of trp with chemical compounds

References

  1. Human growth hormone: complementary DNA cloning and expression in bacteria. Martial, J.A., Hallewell, R.A., Baxter, J.D., Goodman, H.M. Science (1979) [Pubmed]
  2. Molecular pathology of dityrosine cross-links in proteins: structural and functional analysis of four proteins. Balasubramanian, D., Kanwar, R. Mol. Cell. Biochem. (2002) [Pubmed]
  3. Concomitant and hormonally regulated expression of trp genes in bovine aortic endothelial cells. Chang, A.S., Chang, S.M., Garcia, R.L., Schilling, W.P. FEBS Lett. (1997) [Pubmed]
  4. Expression of cloned calf prochymosin cDNA under control of the tryptophan promoter. Nishimori, K., Shimizu, N., Kawaguchi, Y., Hidaka, M., Uozumi, T., Beppu, T. Gene (1984) [Pubmed]
  5. Artificial immunoglobulin G-binding protein mimetic to staphylococcal protein A. Its production and application to affinity purification of immunoglobulin G. Kihira, Y., Aiba, S. J. Chromatogr. (1992) [Pubmed]
  6. Bovine chymosin: production by rDNA technology and application in cheese manufacture. Mohanty, A.K., Mukhopadhyay, U.K., Grover, S., Batish, V.K. Biotechnology advances. (1999) [Pubmed]
  7. Expression vehicles used in recombinant DNA technology. Friesen, J.D., An, G. Biotechnology advances. (1983) [Pubmed]
  8. Fluorescence and stopped-flow studies on the N in equilibrium F transition of serumalbumin. Rudolph, R., Holler, E., Jaenicke, R. Biophys. Chem. (1975) [Pubmed]
 
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