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Gene Review

Upk1b  -  uroplakin 1B

Mus musculus

Synonyms: AI413235, Tspan20, UP1b, UPIb, Upk1, ...
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High impact information on Upk1b

  • Both knockouts had elevated UPIb gene expression, suggesting that this is a general response to defective plaque assembly [1].
  • Using a sensitive approach that combines in-gel glycosidase and protease digestions, permethylation of released glycans, and mass spectrometry, we have elucidated for the first time the native glycoform structures of the mouse UPIa receptor and those of its non-binding homolog, UPIb, and have determined the glycosylation site occupancy [2].
  • Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization [3].


  1. Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. Kong, X.T., Deng, F.M., Hu, P., Liang, F.X., Zhou, G., Auerbach, A.B., Genieser, N., Nelson, P.K., Robbins, E.S., Shapiro, E., Kachar, B., Sun, T.T. J. Cell Biol. (2004) [Pubmed]
  2. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. Xie, B., Zhou, G., Chan, S.Y., Shapiro, E., Kong, X.P., Wu, X.R., Sun, T.T., Costello, C.E. J. Biol. Chem. (2006) [Pubmed]
  3. Assignment of the Uroplakin 1b (Upk1b) gene to mouse chromosome 16 bands B5-C2 by in situ hybridization. Webb, G.C., Finch, J.L., Cowled, P.A. Cytogenet. Cell Genet. (1999) [Pubmed]
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