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Gene Review

UPK1B  -  uroplakin 1B

Homo sapiens

Synonyms: TSPAN20, Tetraspanin-20, Tspan-20, UP1b, UPIB, ...
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Disease relevance of UPK1B


High impact information on UPK1B

  • Human UPIa contained exclusively high mannose glycans, and human UPIb contained only complex glycans [5].
  • Using a sensitive approach that combines in-gel glycosidase and protease digestions, permethylation of released glycans, and mass spectrometry, we have elucidated for the first time the native glycoform structures of the mouse UPIa receptor and those of its non-binding homolog, UPIb, and have determined the glycosylation site occupancy [5].
  • In mammals, UPIII is forming a complex with a tetraspanin molecule uroplakin Ib [6].
  • Cultured normal human urothelial cells showed a proliferative basal/intermediate cell phenotype and constitutive expression of UPIb only [1].
  • Two high-affinity activators of PPARgamma, troglitazone (TZ) and rosiglitazone (RZ) induced the expression of mRNA for UPII and UPIb and, to a lesser extent, UPIa [7].

Biological context of UPK1B


Anatomical context of UPK1B


Associations of UPK1B with chemical compounds


Regulatory relationships of UPK1B


Other interactions of UPK1B

  • Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism [10].
  • The combination of UPIb/UPIII was the most specific (79%) but had modest sensitivity (31%) [11].
  • Analysis of the uroplakin Ib promoter identified a weak CpG island spanning the proximal promoter, exon 1, and the beginning of intron 1 [4].

Analytical, diagnostic and therapeutic context of UPK1B


  1. Uroplakin gene expression by normal and neoplastic human urothelium. Lobban, E.D., Smith, B.A., Hall, G.D., Harnden, P., Roberts, P., Selby, P.J., Trejdosiewicz, L.K., Southgate, J. Am. J. Pathol. (1998) [Pubmed]
  2. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. Olsburgh, J., Harnden, P., Weeks, R., Smith, B., Joyce, A., Hall, G., Poulsom, R., Selby, P., Southgate, J. J. Pathol. (2003) [Pubmed]
  3. Human uroplakin Ib in ocular surface epithelium. Adachi, W., Okubo, K., Kinoshita, S. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  4. Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. Varga, A.E., Leonardos, L., Jackson, P., Marreiros, A., Cowled, P.A. Neoplasia (2004) [Pubmed]
  5. Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia. Xie, B., Zhou, G., Chan, S.Y., Shapiro, E., Kong, X.P., Wu, X.R., Sun, T.T., Costello, C.E. J. Biol. Chem. (2006) [Pubmed]
  6. Molecular identification and characterization of Xenopus egg uroplakin III, an egg raft-associated transmembrane protein that is tyrosine-phosphorylated upon fertilization. Sakakibara, K., Sato, K., Yoshino, K., Oshiro, N., Hirahara, S., Mahbub Hasan, A.K., Iwasaki, T., Ueda, Y., Iwao, Y., Yonezawa, K., Fukami, Y. J. Biol. Chem. (2005) [Pubmed]
  7. Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme. Varley, C.L., Stahlschmidt, J., Lee, W.C., Holder, J., Diggle, C., Selby, P.J., Trejdosiewicz, L.K., Southgate, J. J. Cell. Sci. (2004) [Pubmed]
  8. Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. Finch, J.L., Miller, J., Aspinall, J.O., Cowled, P.A. Int. J. Cancer (1999) [Pubmed]
  9. Human uroplakin lb gene structure and promoter analysis. Olsburgh, J., Weeks, R., Selby, P., Southgate, J. Biochim. Biophys. Acta (2002) [Pubmed]
  10. Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. Finch, J.L., Webb, G.C., Evdokiou, A., Cowled, P.A. Genomics (1997) [Pubmed]
  11. Detection of circulating cancer cells expressing uroplakins and epidermal growth factor receptor in bladder cancer patients. Osman, I., Kang, M., Lee, A., Deng, F.M., Polsky, D., Mikhail, M., Chang, C., David, D.A., Mitra, N., Wu, X.R., Sun, T.T., Bajorin, D.F. Int. J. Cancer (2004) [Pubmed]
  12. Urothelial umbrella cells of human ureter are heterogeneous with respect to their uroplakin composition: different degrees of urothelial maturity in ureter and bladder? Riedel, I., Liang, F.X., Deng, F.M., Tu, L., Kreibich, G., Wu, X.R., Sun, T.T., Hergt, M., Moll, R. Eur. J. Cell Biol. (2005) [Pubmed]
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