High impact information on Dsg1b

• The desmoglein 5 transcript contains an open reading frame of 3180 bp encoding a precursor of 1060 amino acid residues, and the desmoglein 6 transcript contains an open reading frame of 2733 bp encoding a precursor of 911 amino acid residues [1].
• Novel member of the mouse desmoglein gene family: Dsg1-beta [2].
• The full-length mouse Dsg1-beta cDNA contains an open reading frame of 3180 bp encoding a precursor protein of 1060 amino acids [2].
• RT-PCR using a multitissue cDNA panel demonstrated that while Dsg1-alpha mRNA was expressed in 15- to 17-day-old embryos and adult spleen and testis, Dsg1-beta mRNA was detected in 17-day-old embryos only [2].

Biological context of Dsg1b

• However, we recently cloned two novel additional mouse Dsg1 genes, Dsg1-beta and -gamma, which flank the original Dsg1-alpha on chromosome 18 [3].

Anatomical context of Dsg1b

• Dsg1-beta and -gamma, but not Dsg1-alpha, were detected in the sebaceous gland epithelium and the stratified epithelium of the stomach [3].

References