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Gene Review

DUX4L1  -  double homeobox 4 like 1

Homo sapiens

Synonyms: DUX10, DUX4
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Disease relevance of DUX4


High impact information on DUX4

  • We have evaluated the trafficking and mobility of two DUX proteins, DUX1 and DUX4 [2].
  • In addition, these 3.3kb repeats include an open reading frame (ORF) starting 149bp downstream from the TACAA box and encoding a 391 residue protein with two homeodomains (DUX4) [3].
  • In-vitro transcription/translation of the ORF in a rabbit reticulocyte lysate yielded two (35)S Cys/ (35)S Met labeled products with apparent molecular weights of 38 and 75kDa on SDS-PAGE, corresponding to the DUX4 monomer and dimer, respectively [3].


  1. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Kawamura-Saito, M., Yamazaki, Y., Kaneko, K., Kawaguchi, N., Kanda, H., Mukai, H., Gotoh, T., Motoi, T., Fukayama, M., Aburatani, H., Takizawa, T., Nakamura, T. Hum. Mol. Genet. (2006) [Pubmed]
  2. Intracellular trafficking and dynamics of double homeodomain proteins. Ostlund, C., Garcia-Carrasquillo, R.M., Belayew, A., Worman, H.J. Biochemistry (2005) [Pubmed]
  3. Nucleotide sequence of the partially deleted D4Z4 locus in a patient with FSHD identifies a putative gene within each 3.3 kb element. Gabriëls, J., Beckers, M.C., Ding, H., De Vriese, A., Plaisance, S., van der Maarel, S.M., Padberg, G.W., Frants, R.R., Hewitt, J.E., Collen, D., Belayew, A. Gene (1999) [Pubmed]
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