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Gene Review:

PTGR1 - prostaglandin reductase 1

Homo sapiens

Synonyms: 15-oxoprostaglandin 13-reductase, LTB4DH, NADP-dependent leukotriene B4 12-hydroxydehydrogenase, PGR1, PRG-1, ...

Yamamoto, T. et al., Yokomizo, T. et al., Hori, T. et al., Dick, R.A. et al.

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High impact information on LTB4DH

Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase [1].
cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase [2].
Leukotriene B4 12-hydroxydehydrogenase catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4 [2].
We have cloned cDNA for leukotriene B4 12-hydroxydehydrogenase (LTB4 12-HD)/15-ketoprostaglandin 13-reductase (PGR) from guinea-pig liver [3].
LTB4 12-HD catalyzes the conversion of LTB4 into 12-keto-LTB4 in the presence of NADP+, and plays an important role in inactivating LTB4 [3].

Associations of LTB4DH with chemical compounds

Crystal structure of anti-configuration of indomethacin and leukotriene b4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy [4].

References

Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. Dick, R.A., Kwak, M.K., Sutter, T.R., Kensler, T.W. J. Biol. Chem. (2001) [Pubmed]
cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase. Yokomizo, T., Ogawa, Y., Uozumi, N., Kume, K., Izumi, T., Shimizu, T. J. Biol. Chem. (1996) [Pubmed]
Immunohistochemical localization of guinea-pig leukotriene B4 12-hydroxydehydrogenase/15-ketoprostaglandin 13-reductase. Yamamoto, T., Yokomizo, T., Nakao, A., Izumi, T., Shimizu, T. Eur. J. Biochem. (2001) [Pubmed]
Crystal structure of anti-configuration of indomethacin and leukotriene b4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase complex reveals the structural basis of broad spectrum indomethacin efficacy. Hori, T., Ishijima, J., Yokomizo, T., Ago, H., Shimizu, T., Miyano, M. J. Biochem. (2006) [Pubmed]

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AgaP_AGAP000289	Anopheles gambiae str. PEST
AgaP_AGAP000287	Anopheles gambiae str. PEST
AgaP_AGAP000288	Anopheles gambiae str. PEST
AgaP_AGAP000414	Anopheles gambiae str. PEST
AT5G37940	Arabidopsis thaliana
AT5G16990	Arabidopsis thaliana
AT5G16980	Arabidopsis thaliana
AER	Arabidopsis thaliana
AT1G26320	Arabidopsis thaliana
AT3G03080	Arabidopsis thaliana
AT5G16960	Arabidopsis thaliana
AT5G37980	Arabidopsis thaliana
AT5G17000	Arabidopsis thaliana
AT5G38000	Arabidopsis thaliana
AT3G59845	Arabidopsis thaliana
PTGR1	Bos taurus
PTGR1	Canis lupus familiaris
ptgr1	Danio rerio
LOC566996	Danio rerio
PTGR1	Gallus gallus
MGG_11308	Magnaporthe oryzae 70-15
Ptgr1	Mus musculus
NCU09040	Neurospora crassa OR74A
Os04g0497000	Oryza sativa Japonica Group
PTGR1	Pan troglodytes
Ptgr1	Rattus norvegicus
SPAPB24D3.08c	Schizosaccharomyces pombe 972h-
ltb4dh	Xenopus (Silurana) tropicalis
ptgr1.1	Xenopus (Silurana) tropicalis
ptgr1.2	Xenopus (Silurana) tropicalis
LOC100485344	Xenopus (Silurana) tropicalis

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