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Gene Review

FOXD1  -  forkhead box D1

Homo sapiens

Synonyms: FKHL8, FREAC-4, FREAC4, Forkhead box protein D1, Forkhead-related protein FKHL8, ...
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High impact information on FOXD1

  • Thus, Foxd1 modulates inflammatory reactions and prevents autoimmunity by directly regulating anti-inflammatory regulators of the NF-AT pathway, and by coordinating the suppression of the NF-kappaB pathway via Foxj1 [1].
  • Furthermore, we demonstrate that overexpression of Ets-1 in the human embryonic kidney cell line 293 is sufficient to increase freac-4 mRNA levels [2].
  • In cotransfection experiments using an Ets-1 expression vector, the induction of freac-4 reporter gene activity is attenuated approximately 6-fold when the three Ets-1 binding sites are mutated [2].
  • Through transfection experiments three Ets-1 cis-elements are identified within the first 152 nucleotides upstream of the transcription start in the freac-4 promoter [2].
  • There are no similarities in regions outside of the DNA binding domains of FREAC-9 and FREAC-4 and since freac-4 maps to a different chromosome (5q12-q13) it is likely that an evolutionary selection has acted to maintain identical DNA binding domains between these two kidney expressed transcription factors [3].

Biological context of FOXD1

  • The amino acid sequence of the DNA binding forkhead motif of FREAC-9 is identical to that of another forkhead protein, FREAC-4, whereas 12 substitutions are present at the nucleotide level [3].

Analytical, diagnostic and therapeutic context of FOXD1

  • We describe the cloning and sequence analysis of a nearly full-length cDNA as well as a corresponding 5.2-kilobase pair genomic fragment encoding FREAC-4, a member of the forkhead family of transcription factors [4].


  1. Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1. Lin, L., Peng, S.L. J. Immunol. (2006) [Pubmed]
  2. The kidney-expressed winged helix transcription factor FREAC-4 is regulated by Ets-1. A possible role in kidney development. Cederberg, A., Hulander, M., Carlsson, P., Enerbäck, S. J. Biol. Chem. (1999) [Pubmed]
  3. Cloning and characterization of freac-9 (FKHL17), a novel kidney-expressed human forkhead gene that maps to chromosome 1p32-p34. Ernstsson, S., Betz, R., Lagercrantz, S., Larsson, C., Ericksson, S., Cederberg, A., Carlsson, P., Enerbäck, S. Genomics (1997) [Pubmed]
  4. Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53. Ernstsson, S., Pierrou, S., Hulander, M., Cederberg, A., Hellqvist, M., Carlsson, P., Enerbäck, S. J. Biol. Chem. (1996) [Pubmed]
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