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Gene Review

ZHX3  -  zinc fingers and homeoboxes 3

Homo sapiens

Synonyms: KIAA0395, TIX1, Triple homeobox protein 1, Zinc finger and homeodomain protein 3, Zinc fingers and homeoboxes protein 3
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Disease relevance of ZHX3

  • In experimental minimal change disease, ZHX3 was transiently down-regulated prior to the onset of proteinuria, and recovery of expression was associated with migration of ZHX3 protein into the nucleus and the development of proteinuria [1].

High impact information on ZHX3

  • While studying mechanisms of glomerular disease, rat ZHX3 was cloned from a down-regulated gene fragment; its cellular localization, DNA binding, and transcriptional repressor properties were characterized; and its ability to influence podocyte gene expression directly or via ZHX1 and ZHX2 was studied [1].
  • This expression pattern mirrored the increased nuclear ZHX3 expression noted in vivo in the podocytes in human minimal change disease biopsies [1].
  • In vitro, migration of ZHX3 protein into the nucleus during recovery from transient ZHX3 knockdown reproduced the gene expression profile of in vivo minimal change disease [1].
  • Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3 [2].
  • A 4.5-kb ZHX2 transcript, and three ZHX3 transcripts, 9.5-, 6.5- and 4.4-kb, are ubiquitously expressed, although their levels vary [3].

Biological context of ZHX3


Other interactions of ZHX3

  • We concluded that the protein forms the ZHX family with ZHX1 and denoted it ZHX3 [2].


  1. ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome. Liu, G., Clement, L.C., Kanwar, Y.S., Avila-Casado, C., Chugh, S.S. J. Biol. Chem. (2006) [Pubmed]
  2. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. Yamada, K., Kawata, H., Shou, Z., Hirano, S., Mizutani, T., Yazawa, T., Sekiguchi, T., Yoshino, M., Kajitani, T., Miyamoto, K. Biochem. J. (2003) [Pubmed]
  3. The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3. Kawata, H., Yamada, K., Shou, Z., Mizutani, T., Miyamoto, K. Gene (2003) [Pubmed]
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