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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDN  -  dendrin

Homo sapiens

Synonyms: Dendrin, KIAA0749
 
 
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Disease relevance of DDN

  • A total of 55 joints was studied: 32 were diagnosed as displaced disc with reduction [DDR], 10 were diagnosed as displaced disc without reduction [DDN], and 13 were diagnosed as degenerative joint disease [DJD] [1].
 

High impact information on DDN

  • In a yeast two hybrid screen with the human isoform of Dendrin (KIAA0749), a putative modulator of the postsynaptic cytoskeleton, we isolated a cDNA coding for a novel protein, KIBRA, possessing two amino-terminal WW domains, an internal C2-like domain and a carboxy-terminal glutamic acid-rich stretch [2].
  • A search for MAGI-1-interacting proteins by yeast two-hybrid screening of a kidney cDNA library yielded dendrin [3].
  • The first SH3 domain and the C-terminal region of CIN85 bind to the proline-rich region and the N-terminal region of dendrin, respectively [3].

References

  1. The spectral properties of temporomandibular joint sounds. Gay, T., Bertolami, C.N. J. Dent. Res. (1987) [Pubmed]
  2. Characterization of KIBRA, a novel WW domain-containing protein. Kremerskothen, J., Plaas, C., Büther, K., Finger, I., Veltel, S., Matanis, T., Liedtke, T., Barnekow, A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  3. CIN85 is localized at synapses and forms a complex with S-SCAM via dendrin. Kawata, A., Iida, J., Ikeda, M., Sato, Y., Mori, H., Kansaku, A., Sumita, K., Fujiwara, N., Rokukawa, C., Hamano, M., Hirabayashi, S., Hata, Y. J. Biochem. (2006) [Pubmed]
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