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Gene Review

SYT11  -  synaptotagmin XI

Homo sapiens

Synonyms: DKFZp781D015, KIAA0080, MGC10881, MGC17226, SYT12, ...
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Disease relevance of SYT11


High impact information on SYT11


Anatomical context of SYT11

  • Since synaptotagmin XI is a member of the synaptotagmin family that is well characterized in their importance for vesicle formation and docking, the interaction with this protein suggests a role for parkin in the regulation of the synaptic vesicle pool and in vesicle release [1].

Other interactions of SYT11

  • Synaptotagmin XI is linked to the pathogenesis of PD based on its identification as a substrate of the ubiquitin-E3-ligase parkin [2].


  1. The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Huynh, D.P., Scoles, D.R., Nguyen, D., Pulst, S.M. Hum. Mol. Genet. (2003) [Pubmed]
  2. Screening for mutations in synaptotagmin XI in Parkinson's disease. Glass, A.S., Huynh, D.P., Franck, T., Woitalla, D., Müller, T., Pulst, S.M., Berg, D., Krüger, R., Riess, O. J. Neural Transm. Suppl. (2004) [Pubmed]
  3. Polymorphic 33-bp repeats with promoter-like activity in synaptotagmin 11 gene. Yokota, H., Tsujita, T., Okazaki, Y., Kikuya, E., Oishi, M. DNA Res. (2003) [Pubmed]
  4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. Nomura, N., Nagase, T., Miyajima, N., Sazuka, T., Tanaka, A., Sato, S., Seki, N., Kawarabayasi, Y., Ishikawa, K., Tabata, S. DNA Res. (1994) [Pubmed]
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