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Gene Review:

ACAP2 - ArfGAP with coiled-coil, ankyrin repeat...

Homo sapiens

Synonyms: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2, CENTB2, CNT-B2, Centaurin-beta-2, Cnt-b2, ...

Meng, X. et al., Jackson, T.R. et al., Nomura, N. et al.

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Disease relevance of CENTB2

Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2 [1].

High impact information on CENTB2

ACAP1 and ACAP2 are widely expressed and occur together in the various cultured cell lines we examined [2].
Similar to ASAP1, ACAP1 and ACAP2 were recruited to and, when overexpressed, inhibited the formation of platelet-derived growth factor (PDGF)-induced dorsal membrane ruffles in NIH 3T3 fibroblasts [2].
In addition, ACAP1 and ACAP2 were recruited to peripheral, tubular membranes, where activation of Arf6 occurs to allow membrane recycling back to the plasma membrane [2].
These substitutions, however, did not affect K1L's ability to bind ACAP2, a GTPase-activating protein for ARF6 [1].
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 [3].

References

Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2. Meng, X., Xiang, Y. Virology (2006) [Pubmed]
ACAPs are arf6 GTPase-activating proteins that function in the cell periphery. Jackson, T.R., Brown, F.D., Nie, Z., Miura, K., Foroni, L., Sun, J., Hsu, V.W., Donaldson, J.G., Randazzo, P.A. J. Cell Biol. (2000) [Pubmed]
Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. Nomura, N., Nagase, T., Miyajima, N., Sazuka, T., Tanaka, A., Sato, S., Seki, N., Kawarabayasi, Y., Ishikawa, K., Tabata, S. DNA Res. (1994) [Pubmed]

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AgaP_AGAP000563	Anopheles gambiae str. PEST
AGD2	Arabidopsis thaliana
AGD4	Arabidopsis thaliana
cnt-1	Caenorhabditis elegans
ACAP2	Canis lupus familiaris
CenB1A	Drosophila melanogaster
ACAP2	Gallus gallus
ACAP2	Macaca mulatta
Acap2	Mus musculus
Os02g0632500	Oryza sativa Japonica Group
ACAP2	Pan troglodytes
Acap2	Rattus norvegicus
acap2	Xenopus (Silurana) tropicalis

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