Gene Review:
PARK2 - parkin RBR E3 ubiquitin protein ligase
Homo sapiens
Synonyms:
AR-JP, E3 ubiquitin-protein ligase parkin, LPRS2, PDJ, PRKN, ...
Takahashi,
Vidal,
Shimura,
Uchihara,
Gai,
Lin,
Madura,
Doss-Pepe,
Kachergus,
Takahashi,
Selkoe,
Morales,
Kosik,
Lockhart,
Wakabayashi,
Lincoln,
LaVoie,
Ampuero,
Berciano,
Sharon,
del Ser,
Langston,
Mizuno,
Mizuno,
Schlossmacher,
Weihofen,
Amino,
Jiménez-Jiménez,
Ostaszewski,
Medina,
Schlossmacher,
Orimo,
Yokochi,
Frosch,
Feany,
Imai,
Hattori,
Hoenicka,
Wu,
Takahashi,
Jiménez,
Sharma,
Forno,
Chen,
Hyman,
Kojo,
Selkoe,
Ochiishi,
de Yébenes,
Farrer,
Bounds,
Hattori,
Pallanck,
Ruíz,
Hulihan,
- Dopamine covalently modifies and functionally inactivates parkin. LaVoie, M.J., Ostaszewski, B.L., Weihofen, A., Schlossmacher, M.G., Selkoe, D.J. Nat. Med. (2005)
- Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. Agirre, X., Román-Gómez, J., Vázquez, I., Jiménez-Velasco, A., Garate, L., Montiel-Duarte, C., Artieda, P., Cordeu, L., Lahortiga, I., Calasanz, M.J., Heiniger, A., Torres, A., Minna, J.D., Prósper, F. Int. J. Cancer (2006)
- PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever. Ali, S., Vollaard, A.M., Widjaja, S., Surjadi, C., van de Vosse, E., van Dissel, J.T. Clin. Exp. Immunol. (2006)
- Susceptibility to leprosy is associated with PARK2 and PACRG. Mira, M.T., Alcaïs, A., Nguyen, V.T., Moraes, M.O., Di Flumeri, C., Vu, H.T., Mai, C.P., Nguyen, T.H., Nguyen, N.B., Pham, X.K., Sarno, E.N., Alter, A., Montpetit, A., Moraes, M.E., Moraes, J.R., Doré, C., Gallant, C.J., Lepage, P., Verner, A., Van De Vosse, E., Hudson, T.J., Abel, L., Schurr, E. Nature (2004)
- Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation. Avraham, E., Rott, R., Liani, E., Szargel, R., Engelender, S. J. Biol. Chem. (2007)
- alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. Kawahara, K., Hashimoto, M., Bar-On, P., Ho, G.J., Crews, L., Mizuno, H., Rockenstein, E., Imam, S.Z., Masliah, E. J. Biol. Chem. (2008)
- Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Schlossmacher, M.G., Frosch, M.P., Gai, W.P., Medina, M., Sharma, N., Forno, L., Ochiishi, T., Shimura, H., Sharon, R., Hattori, N., Langston, J.W., Mizuno, Y., Hyman, B.T., Selkoe, D.J., Kosik, K.S. Am. J. Pathol. (2002)
- Rapid eye movement sleep behavior disorder in parkinsonism with parkin mutations. Kumru, H., Santamaria, J., Tolosa, E., Valldeoriola, F., Muñoz, E., Marti, M.J., Iranzo, A. Ann. Neurol. (2004)
- Cardiac sympathetic denervation in Lewy body disease. Orimo, S., Amino, T., Takahashi, A., Kojo, T., Uchihara, T., Mori, F., Wakabayashi, K., Takahashi, H. Parkinsonism Relat. Disord. (2006)
- Co-occurrence of restless legs syndrome and Parkin mutations in two families. Adel, S., Djarmati, A., Kabakci, K., Pichler, I., Eskelson, C., Lohnau, T., Kock, N., Hagenah, J., Hedrich, K., Schwinger, E., Kramer, P.L., Pramstaller, P.P., Klein, C. Mov. Disord. (2006)
- Parkin mutation associated parkinsonism and cognitive decline, comparison to early onset Parkinson's disease. Benbunan, B.R., Korczyn, A.D., Giladi, N. Journal of neural transmission (Vienna, Austria : 1996) (2004)
- The biochemistry of Parkinson's disease. Cookson, M.R. Annu. Rev. Biochem. (2005)
- Parc: a cytoplasmic anchor for p53. Nikolaev, A.Y., Li, M., Puskas, N., Qin, J., Gu, W. Cell (2003)
- An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., Takahashi, R. Cell (2001)
- Parkin: a multipurpose neuroprotective agent? Feany, M.B., Pallanck, L.J. Neuron (2003)
- Parkin increases dopamine uptake by enhancing the cell surface expression of dopamine transporter. Jiang, H., Jiang, Q., Feng, J. J. Biol. Chem. (2004)
- Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2. Orimo, S., Amino, T., Yokochi, M., Kojo, T., Uchihara, T., Takahashi, A., Wakabayashi, K., Takahashi, H., Hattori, N., Mizuno, Y. Mov. Disord. (2005)
- Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Jiang, H., Ren, Y., Zhao, J., Feng, J. Hum. Mol. Genet. (2004)
- Diverse effects of pathogenic mutations of Parkin that catalyze multiple monoubiquitylation in vitro. Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K. J. Biol. Chem. (2006)
- Genetic dissection of immunity in leprosy. Alcaïs, A., Mira, M., Casanova, J.L., Schurr, E., Abel, L. Curr. Opin. Immunol. (2005)
- Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Denison, S.R., Callahan, G., Becker, N.A., Phillips, L.A., Smith, D.I. Genes Chromosomes Cancer (2003)
- A microdeletion of D6S305 in a family of autosomal recessive juvenile parkinsonism (PARK2). Matsumine, H., Yamamura, Y., Hattori, N., Kobayashi, T., Kitada, T., Yoritaka, A., Mizuno, Y. Genomics (1998)
- Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism. Lesage, S., Magali, P., Lohmann, E., Lacomblez, L., Teive, H., Janin, S., Cousin, P.Y., D??rr, A., Brice, A. Hum. Mutat. (2007)
- Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Chung, K.K., Zhang, Y., Lim, K.L., Tanaka, Y., Huang, H., Gao, J., Ross, C.A., Dawson, V.L., Dawson, T.M. Nat. Med. (2001)
- Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress. Moore, D.J., Zhang, L., Troncoso, J., Lee, M.K., Hattori, N., Mizuno, Y., Dawson, T.M., Dawson, V.L. Hum. Mol. Genet. (2005)
- Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. Imai, Y., Soda, M., Takahashi, R. J. Biol. Chem. (2000)
- Lack of mutations in DJ-1 in a cohort of Taiwanese ethnic Chinese with early-onset parkinsonism. Lockhart, P.J., Bounds, R., Hulihan, M., Kachergus, J., Lincoln, S., Lin, C.H., Wu, R.M., Farrer, M.J. Mov. Disord. (2004)
- Alpha-synuclein and parkin contribute to the assembly of ubiquitin lysine 63-linked multiubiquitin chains. Doss-Pepe, E.W., Chen, L., Madura, K. J. Biol. Chem. (2005)
- Molecular findings in familial Parkinson disease in Spain. Hoenicka, J., Vidal, L., Morales, B., Ampuero, I., Jiménez-Jiménez, F.J., Berciano, J., del Ser, T., Jiménez, A., Ruíz, P.G., de Yébenes, J.G. Arch. Neurol. (2002)
- Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition. Bandopadhyay, R., Kingsbury, A.E., Muqit, M.M., Harvey, K., Reid, A.R., Kilford, L., Engelender, S., Schlossmacher, M.G., Wood, N.W., Latchman, D.S., Harvey, R.J., Lees, A.J. Neurobiol. Dis. (2005)
- Cell type-specific upregulation of Parkin in response to ER stress. Wang, H.Q., Imai, Y., Kataoka, A., Takahashi, R. Antioxid. Redox Signal. (2007)
- A family with Parkinson disease, essential tremor, bell palsy, and parkin mutations. Deng, H., Le, W.D., Hunter, C.B., Mejia, N., Xie, W.J., Jankovic, J. Arch. Neurol. (2007)
- Co-association of parkin and alpha-synuclein. Choi, P., Golts, N., Snyder, H., Chong, M., Petrucelli, L., Hardy, J., Sparkman, D., Cochran, E., Lee, J.M., Wolozin, B. Neuroreport (2001)
- The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI. Huynh, D.P., Scoles, D.R., Nguyen, D., Pulst, S.M. Hum. Mol. Genet. (2003)
- Parkin ubiquitinates and promotes the degradation of RanBP2. Um, J.W., Min, d.o. .S., Rhim, H., Kim, J., Paik, S.R., Chung, K.C. J. Biol. Chem. (2006)
- Pael receptor, endoplasmic reticulum stress, and Parkinson's disease. Takahashi, R., Imai, Y. J. Neurol. (2003)
- Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Shimura, H., Schlossmacher, M.G., Hattori, N., Frosch, M.P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K.S., Selkoe, D.J. Science (2001)
- A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. Imai, Y., Soda, M., Murakami, T., Shoji, M., Abe, K., Takahashi, R. J. Biol. Chem. (2003)
- Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1. Zhang, Y., Gao, J., Chung, K.K., Huang, H., Dawson, V.L., Dawson, T.M. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Clinical features and gene analysis in Korean patients with early-onset Parkinson disease. Chung, E.J., Ki, C.S., Lee, W.Y., Kim, I.S., Kim, J.Y. Arch. Neurol. (2006)
- Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Smith, W.W., Pei, Z., Jiang, H., Moore, D.J., Liang, Y., West, A.B., Dawson, V.L., Dawson, T.M., Ross, C.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Correlated break at PARK2/FRA6E and loss of AF-6/Afadin protein expression are associated with poor outcome in breast cancer. Letessier, A., Garrido-Urbani, S., Ginestier, C., Fournier, G., Esterni, B., Monville, F., Ad??la??de, J., Geneix, J., Xerri, L., Dubreuil, P., Viens, P., Charafe-Jauffret, E., Jacquemier, J., Birnbaum, D., Lopez, M., Chaffanet, M. Oncogene (2007)
- Parkin gene therapy for alpha-synucleinopathy: a rat model of Parkinson's disease. Yamada, M., Mizuno, Y., Mochizuki, H. Hum. Gene Ther. (2005)