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Gene Review

ARHGEF9  -  Cdc42 guanine nucleotide exchange factor...

Homo sapiens

Synonyms: ARHDH9, COLLYBISTIN, Collybistin, EIEE8, HPEM-2, ...
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High impact information on ARHGEF9


Biological context of ARHGEF9


Anatomical context of ARHGEF9

  • Glycine receptors (GlyRs) and specific subtypes of GABA(A) receptors are clustered at synapses by the multidomain protein gephyrin, which in turn is translocated to the cell membrane by the GDP-GTP exchange factor collybistin [5].

Associations of ARHGEF9 with chemical compounds


Physical interactions of ARHGEF9


Other interactions of ARHGEF9

  • Here we describe two splice variants of a novel gephyrin-binding protein, termed collybistin I and II, which belong to the family of dbl-like GDP/GTP exchange factors (GEFs) [1].
  • Expression of ARHGEF4 is restricted to brain and the encoded protein shows homology to collybistin [7].


  1. Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Kins, S., Betz, H., Kirsch, J. Nat. Neurosci. (2000) [Pubmed]
  2. Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. Reid, T., Bathoorn, A., Ahmadian, M.R., Collard, J.G. J. Biol. Chem. (1999) [Pubmed]
  3. The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor. Xiang, S., Kim, E.Y., Connelly, J.J., Nassar, N., Kirsch, J., Winking, J., Schwarz, G., Schindelin, H. J. Mol. Biol. (2006) [Pubmed]
  4. Posterior end mark 2 (pem-2), pem-4, pem-5, and pem-6: maternal genes with localized mRNA in the ascidian embryo. Satou, Y., Satoh, N. Dev. Biol. (1997) [Pubmed]
  5. The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. Harvey, K., Duguid, I.C., Alldred, M.J., Beatty, S.E., Ward, H., Keep, N.H., Lingenfelter, S.E., Pearce, B.R., Lundgren, J., Owen, M.J., Smart, T.G., Lüscher, B., Rees, M.I., Harvey, R.J. J. Neurosci. (2004) [Pubmed]
  6. Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. Grosskreutz, Y., Hermann, A., Kins, S., Fuhrmann, J.C., Betz, H., Kneussel, M. Biol. Chem. (2001) [Pubmed]
  7. Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. Thiesen, S., Kübart, S., Ropers, H.H., Nothwang, H.G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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