Disease relevance of SLC39A14

• Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response [1].
• Because NTBI is commonly found in plasma of patients with hemochromatosis and transfusional iron overload, Zip14-mediated NTBI uptake may contribute to the hepatic iron loading that characterizes these diseases [2].

High impact information on SLC39A14

• Zip14 was found to localize to the plasma membrane, and its overexpression increased the uptake of both (65)Zn and (59)Fe [2].
• Suppression of endogenous Zip14 expression by using Zip14 siRNA reduced the uptake of both iron and zinc by AML12 mouse hepatocytes [2].
• Up-regulation of Zip14 by IL-6 appears to contribute to the hepatic zinc accumulation and hypozincemia of inflammation [2].
• Addition of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediated iron uptake from ferric citrate, suggesting that iron is taken up by HEK cells as Fe(2+) [2].
• Transfection of mZip14 cDNA into human embryonic kidney cells increased zinc uptake as measured by both a fluorescent probe for free Zn(2+) and (65)Zn accumulation, as well as by metallothionein mRNA induction, all indicating that Zip14 functions as a zinc importer [1].

Biological context of SLC39A14

• Northern analysis showed Zip14 up-regulation was specific for the liver, with one major transcript [1].

Anatomical context of SLC39A14

• Zip14 was localized in plasma membrane of the transfected cells [1].
• IL-6 produced increased expression of Zip14 in primary hepatocytes cultures and localization of the protein to the plasma membrane [1].

Associations of SLC39A14 with chemical compounds

• We investigate here whether ZIP14 (SLC39A14), lacking the initial histidine in this motif, is still able to transport zinc [3].

Other interactions of SLC39A14

• Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14 [3].

Analytical, diagnostic and therapeutic context of SLC39A14

• Immunohistochemistry, using an antibody to an extracellular Zip14 epitope, showed both LPS and turpentine increased abundance of Zip14 at the plasma membrane of hepatocytes [1].

References