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Gene Review

SLC39A6  -  solute carrier family 39 (zinc...

Homo sapiens

Synonyms: Estrogen-regulated protein LIV-1, LIV-1, LIV1, Solute carrier family 39 member 6, ZIP-6, ...
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Disease relevance of SLC39A6


High impact information on SLC39A6


Chemical compound and disease context of SLC39A6

  • The mRNA levels of LIV-1 and pS2, two estrogen-responsive genes, are increased by the agents, cholera toxin (CT) plus 3-isobutyl-l-methylxanthine (IBMX), which cause an increase in cAMP in MCF-7 human breast cancer cells [5].

Biological context of SLC39A6

  • Investigation of the protein product of the oestrogen-regulated gene LIV-1, implicated in metastatic breast cancer, has revealed 10 protein sequences of unknown function that belong to a new family with potential to control intracellular Zn2+ homeostasis [6].
  • Furthermore, we demonstrate that LIV1 is essential for the nuclear localization of zinc-finger protein Snail, a master regulator of EMT [7].

Anatomical context of SLC39A6

  • Recombinant LIV-1 locates to the plasma membrane, concentrated in lamellipodiae, similar to membrane-type metalloproteases [2].
  • The LIV-1 gene has been previously associated with oestrogen-positive breast cancer and its metastatic spread to the regional lymph nodes [2].
  • We identified at least two zinc transporters in both human mesenchymal stem cells (MSCs) and in osteoblastic cells--the ubiquitous zinc transporter, ZIP1, and LIV-1, which was previously characterized as a protein that is expressed in breast cancer cells [8].
  • Here we identify LIV1, a breast-cancer-associated zinc transporter protein, as a downstream target of STAT3 that is essential and sufficient for STAT3's cell-autonomous role in the EMT of zebrafish gastrula organizer cells [7].

Associations of SLC39A6 with chemical compounds

  • Eleven of these genes had previously been associated with estrogen regulation or breast tumorigenesis including trefoil factor 1 and estrogen regulated LIV-1 [9].

Other interactions of SLC39A6


  1. Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients. Kasper, G., Weiser, A.A., Rump, A., Sparbier, K., Dahl, E., Hartmann, A., Wild, P., Schwidetzky, U., Castaños-Vélez, E., Lehmann, K. Int. J. Cancer (2005) [Pubmed]
  2. Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. Taylor, K.M., Morgan, H.E., Johnson, A., Hadley, L.J., Nicholson, R.I. Biochem. J. (2003) [Pubmed]
  3. Zinc transporter LIV-1: a link between cellular development and cancer progression. Taylor, K.M., Hiscox, S., Nicholson, R.I. Trends Endocrinol. Metab. (2004) [Pubmed]
  4. Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. Taylor, K.M., Morgan, H.E., Johnson, A., Nicholson, R.I. FEBS Lett. (2005) [Pubmed]
  5. Interaction between estradiol and cAMP in the regulation of specific gene expression. el-Tanani, M.K., Green, C.D. Mol. Cell. Endocrinol. (1996) [Pubmed]
  6. LIV-1 breast cancer protein belongs to new family of histidine-rich membrane proteins with potential to control intracellular Zn2+ homeostasis. Taylor, K.M. IUBMB Life (2000) [Pubmed]
  7. Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Yamashita, S., Miyagi, C., Fukada, T., Kagara, N., Che, Y.S., Hirano, T. Nature (2004) [Pubmed]
  8. Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells. Tang, Z., Sahu, S.N., Khadeer, M.A., Bai, G., Franklin, R.B., Gupta, A. Bone (2006) [Pubmed]
  9. Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies. Dressman, M.A., Walz, T.M., Lavedan, C., Barnes, L., Buchholtz, S., Kwon, I., Ellis, M.J., Polymeropoulos, M.H. Pharmacogenomics J. (2001) [Pubmed]
  10. Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. Taylor, K.M., Morgan, H.E., Johnson, A., Nicholson, R.I. Biochem. J. (2004) [Pubmed]
  11. Interaction between estradiol and growth factors in the regulation of specific gene expression in MCF-7 human breast cancer cells. El-Tanani, M.K., Green, C.D. J. Steroid Biochem. Mol. Biol. (1997) [Pubmed]
  12. Insulin/IGF-1 modulation of the expression of two estrogen-induced genes in MCF-7 cells. el-Tanani, M.K., Green, C.D. Mol. Cell. Endocrinol. (1996) [Pubmed]
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