The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

RUSC1  -  RUN and SH3 domain containing 1

Homo sapiens

Synonyms: NESCA, Nesca, New molecule containing SH3 at the carboxy-terminus, RUN and SH3 domain-containing protein 1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on RUSC1

  • Overexpression studies in PC12 cells indicate that Nesca facilitates neurotrophin-dependent neurite outgrowth at nonsaturating doses of nerve growth factor (NGF) [1].
  • We provide the first characterization of a novel signaling adapter, Nesca, in neurotrophic signal transduction [1].
  • Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth [1].
  • RUSC1 isoform 1 (1039 aa) and RUSC2 (1516 aa) showed 30.5% total amino-acid identity [2].
  • RUSC1 gene, consisting of 11 exons, was mapped to human chromosome 1q22 [2].
 

Biological context of RUSC1

 

Analytical, diagnostic and therapeutic context of RUSC1

  • Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3 [3].

References

  1. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. MacDonald, J.I., Kubu, C.J., Meakin, S.O. J. Cell Biol. (2004) [Pubmed]
  2. Characterization of RUSC1 and RUSC2 genes in silico. Katoh, M., Katoh, M. Oncol. Rep. (2004) [Pubmed]
  3. Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3. Matsuda, S., Miyazaki, K., Ichigotani, Y., Kurata, H., Takenouchi, Y., Yamamoto, T., Nimura, Y., Irimura, T., Nakatsugawa, S., Hamaguchi, M. Biochim. Biophys. Acta (2000) [Pubmed]
 
WikiGenes - Universities