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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ZKSCAN5  -  zinc finger with KRAB and SCAN domains 5

Homo sapiens

Synonyms: KIAA1015, ZFP95, ZNF914, ZSCAN37, Zfp-95, ...
 
 
 
 
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High impact information on ZKSCAN5

  • Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain [1].
  • Finally, we show that ZFP95 maps on human chromosome 7q22 between the markers D7S651 and WI-5853 [1].
  • We demonstrate that ZFP95 is ubiquitously expressed in adult and fetal tissues with the strongest expression in testis [1].
  • Sequence comparison revealed that ZFP95 is the human ortholog of murine Zfp95, which is differentially expressed during spermatogenesis [1].
  • RT-PCR analysis confirmed alternative splicing for the KRAB A domain and an upstream exon leading to three transcripts of ZFP95 with and without this transcriptional repressor domain [1].
 

Analytical, diagnostic and therapeutic context of ZKSCAN5

  • Sequence analysis indicates that ZFP95 contains 12 highly conserved zinc finger motifs at the C-terminus and a SCAN box as well as a KRAB A domain at the N-terminus of the protein [1].

References

  1. Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain. Dreyer, S.D., Zheng, Q., Zabel, B., Winterpacht, A., Lee, B. Genomics (1999) [Pubmed]
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