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Gene Review

SMPX  -  small muscle protein, X-linked

Homo sapiens

Synonyms: DFN6, DFNX4, SRMX, Small muscular protein, Stretch-responsive skeletal muscle protein
 
 
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Disease relevance of SMPX

 

High impact information on SMPX

  • 1. On searching expressed and genomic databases, 21 expressed sequence tags were found that allowed the assignment of a human extended consensus sequence of 887 bp, suggesting a completely expressed gene symbolized as SMPX [2].
  • Using mRNA differential display, we found an expression sequence tag (EST) differentially expressed in F1 hybrids and their parents, designated as EST55, which was homologous to human and murine skeletal muscle protein (SMPX), and the full-length cDNA of porcine SMPX was cloned by the rapid amplification of cDNA end (RACE) method [3].
  • The possible relationship between porcine SMPX and heterosis was discussed [3].

References

  1. Identification of a novel stretch-responsive skeletal muscle gene (Smpx). Kemp, T.J., Sadusky, T.J., Simon, M., Brown, R., Eastwood, M., Sassoon, D.A., Coulton, G.R. Genomics (2001) [Pubmed]
  2. Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein. Patzak, D., Zhuchenko, O., Lee, C.C., Wehnert, M. Hum. Genet. (1999) [Pubmed]
  3. Cloning and Identification of Porcine SMPX Differentially Expressed in F1 Crossbreds and Their Parents. Ren, Z.Q., Xiong, Y.Z., Deng, C.Y., Lei, M.G. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
 
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