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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Hybrid Vigor

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High impact information on Hybrid Vigor

  • Molecular basis for heterosis for myelin basic protein content in mice [1].
  • We therefore believe that heterosis for brain MBP content in the F1 hybrid may be regulated at the transcriptional or post-transcriptional level [1].
  • However, Esr2(+/-) mice do develop more severe clinical disease with an earlier onset indicating that heterosis at Esr2 plays a significant role in regulating EAE in males [2].
  • We propose that heterosis provides a mechanism to compensate for UCP1 deficiency [3].
  • Specificity controls eliminate the possibility that the differential uptake is due to Fc receptor binding or undefined effects of hybrid vigor [4].

Biological context of Hybrid Vigor


Anatomical context of Hybrid Vigor


Associations of Hybrid Vigor with chemical compounds

  • The results for both the DRD1 and DRD2 genes, which have opposing effects on cyclic AMP, were consistent with negative and positive heterosis, respectively [11].
  • It was concluded that multilocus probe DFP of pooled DNA samples show promise as predictors of heterosis [12].
  • F1 hybrids of crosses between two widely studied wild-type strains, N2 (var. Bristol) and Berg BO (var. Bergerac), were examined for rate of development, hermaphrodite fertility, and behavior; there was no heterosis for these life history traits [13].
  • Analysis of the whole brain for several myelin-associated constituents such as GM1 ganglioside, 2',3'-cyclic nucleotide 3'-phosphohydrolase (CNPase), 5'-nucleotidase, and carbonic anhydrase indicated that heterosis exists for these components [14].
  • Similarity indices between different parental combinations, calculated based on seed esterase polymorphism, showed a significant negative correlation (r = -0.479, P = 0.05) with heterosis for carotenoid content [15].

Gene context of Hybrid Vigor

  • The possible role of HUMMLC2B and its relation to porcine heterosis are discussed [16].
  • The positive heterosis effects with respect to nicotine addiction and personality support the idea that the TPH1 gene exerts pleiotropic effects [17].
  • With one exception, heterosis was not an important source of variation for shank width or shank depth and there was a low level of heterosis for shank length [18].
  • Heterosis was 8.2% for ADG [19].
  • Heterosis percentages were significant for AVBF (7.2%; P less than .01), BF10 (8.8%; P less than .01), DRS% (1.5%; P less than .01), ADG (11.5%; P less than .01), DFC (10.2%; P less than .01), LNGN (10.6%; P less than .01), and LNEF (6.0%; P less than .05) [20].

Analytical, diagnostic and therapeutic context of Hybrid Vigor


  1. Molecular basis for heterosis for myelin basic protein content in mice. Miskimins, R., Ebato, H., Seyfried, T.N., Yu, R.K. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Estrogen receptor-1 (Esr1) and -2 (Esr2) regulate the severity of clinical experimental allergic encephalomyelitis in male mice. Polanczyk, M., Yellayi, S., Zamora, A., Subramanian, S., Tovey, M., Vandenbark, A.A., Offner, H., Zachary, J.F., Fillmore, P.D., Blankenhorn, E.P., Gustafsson, J.A., Teuscher, C. Am. J. Pathol. (2004) [Pubmed]
  3. Effects of genetic background on thermoregulation and fatty acid-induced uncoupling of mitochondria in UCP1-deficient mice. Hofmann, W.E., Liu, X., Bearden, C.M., Harper, M.E., Kozak, L.P. J. Biol. Chem. (2001) [Pubmed]
  4. Allogeneic placenta is a paternal strain antigen immunoabsorbent. Wegmann, T.G., Singh, B., Carlson, G.A. J. Immunol. (1979) [Pubmed]
  5. Negative complementation at the notch locus of Drosophila melanogaster. Foster, G.G. Genetics (1975) [Pubmed]
  6. Selection for growth does not affect apparent energetic efficiency of jejunal glucose uptake in mice. Fan, Y.K., Croom, W.J., Eisen, E.J., Daniel, L.R., Black, B.L., McBride, B.W. J. Nutr. (1996) [Pubmed]
  7. Association of the serotonin transporter gene with serum cholesterol levels and heart disease. Comings, D.E., MacMurray, J.P., Gonzalez, N., Ferry, L., Peters, W.R. Mol. Genet. Metab. (1999) [Pubmed]
  8. Identification of novel non-insulin-dependent diabetes mellitus susceptibility loci in the Otsuka Long-Evans Tokushima fatty rat by MQM-mapping method. Sugiura, K., Miyake, T., Taniguchi, Y., Yamada, T., Moralejo, D.H., Wei, S., Wei, K., Sasaki, Y., Matsumoto, K. Mamm. Genome (1999) [Pubmed]
  9. The TaqI A1 allele of the dopamine D2 receptor gene and alcoholism in Brazil: association and interaction with stress and harm avoidance on severity prediction. Bau, C.H., Almeida, S., Hutz, M.H. Am. J. Med. Genet. (2000) [Pubmed]
  10. Heterosis for concentrations of dopamine, norepinephrine, their metabolites, and epinephrine in the chick hyperstriatum ventrale, hypothalamus, and optic tectum. Barbato, G.F., Kruzelock, R.P. Behav. Genet. (1992) [Pubmed]
  11. Studies of the potential role of the dopamine D1 receptor gene in addictive behaviors. Comings, D.E., Gade, R., Wu, S., Chiu, C., Dietz, G., Muhleman, D., Saucier, G., Ferry, L., Rosenthal, R.J., Lesieur, H.R., Rugle, L.J., MacMurray, P. Mol. Psychiatry (1997) [Pubmed]
  12. Prediction of heterosis from DNA fingerprints in chickens. Gavora, J.S., Fairfull, R.W., Benkel, B.F., Cantwell, W.J., Chambers, J.R. Genetics (1996) [Pubmed]
  13. Absence of strong heterosis for life span and other life history traits in Caenorhabditis elegans. Johnson, T.E., Hutchinson, E.W. Genetics (1993) [Pubmed]
  14. Biochemical study of heterosis for brain myelin content in mice. Ebato, H., Seyfried, T.N., Yu, R.K. J. Neurochem. (1983) [Pubmed]
  15. Exploitation of heterosis for carotenoid content in African marigold (Tagetes erecta L.) and its correlation with esterase polymorphism. Sreekala, C., Raghava, S.P. Theor. Appl. Genet. (2003) [Pubmed]
  16. Identification of a differential gene HUMMLC2B between F1 hybrids Landrace x Yorkshire and their female parents Yorkshire. Xu, D.Q., Xiong, Y.Z., Ling, X.F., Lan, J., Liu, M., Deng, C.Y., Jiang, S.W., Lei, M.G. Gene (2005) [Pubmed]
  17. Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality. Reuter, M., Hennig, J. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  18. Effect of crossing a line selected for increased shank width with two commercial sire lines on performance and walking ability of turkeys. Nestor, K.E., Anderson, J.W. Poult. Sci. (1998) [Pubmed]
  19. Performance of Duroc and Yorkshire boars and gilts and reciprocal breed crosses. Bereskin, B., Steele, N.C. J. Anim. Sci. (1986) [Pubmed]
  20. Heterosis and recombination effects in Hampshire and Landrace swine: II. Performance and carcass traits. Baas, T.J., Christian, L.L., Rothschild, M.F. J. Anim. Sci. (1992) [Pubmed]
  21. The impact of maternal uterine genotype on postnatal growth and adult body size in mice. Cowley, D.E., Pomp, D., Atchley, W.R., Eisen, E.J., Hawkins-Brown, D. Genetics (1989) [Pubmed]
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