Disease relevance of C3CER1

• The proportion of tumors with C3CER1 deletions was high in all tumor types investigated, ranging from 70% to 94%, except for the soft-tissue sarcomas (40%) [1].
• Because it was found that similar regions were eliminated in an inter- and intraspecies system and in two tumor types (mouse fibrosarcoma and human renal cell carcinoma), we hypothesized that the importance of C3CER1 would transgress tissue specificity, that is, it could occur in tumors derived from multiple tissues [1].
• Based on a new analysis of the microcell hybrid-derived panel of SCID tumours we also redefined the centromeric border of the C3CER1 [2].

High impact information on C3CER1

• 3. This segment, called chromosome 3 common eliminated region 1 (C3CER1, also referred to as CER1), may harbor multiple tumor-suppressor genes [1].
• A striking feature of C3CER1 is a presence of a cluster of eight chemokine receptor genes [2].
• The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression [3].

Biological context of C3CER1

• We compared 1.32 Mb of C3CER1 (referred also as CER1) from human Chromosome (Chr) 3p21.3 to its orthologous regions on mouse Chr 9F [4].

References