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Gene Review

LIMD1  -  LIM domains containing 1

Homo sapiens

Synonyms: LIM domain-containing protein 1
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Disease relevance of LIMD1


High impact information on LIMD1


Biological context of LIMD1

  • We characterized the genomic structure of the human LIMD1 gene and assigned the mouse Limd1 gene to the chromosome 9F subtelomeric region [5].

Other interactions of LIMD1

  • The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression [5].


  1. LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription. Sharp, T.V., Munoz, F., Bourboulia, D., Presneau, N., Darai, E., Wang, H.W., Cannon, M., Butcher, D.N., Nicholson, A.G., Klein, G., Imreh, S., Boshoff, C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. The LIM Protein, LIMD1, Regulates AP-1 Activation through an Interaction with TRAF6 to Influence Osteoclast Development. Feng, Y., Zhao, H., Luderer, H.F., Epple, H., Faccio, R., Ross, F.P., Teitelbaum, S.L., Longmore, G.D. J. Biol. Chem. (2007) [Pubmed]
  3. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. Petit, M.M., Crombez, K.R., Vervenne, H.B., Weyns, N., Van de Ven, W.J. FEBS Lett. (2005) [Pubmed]
  4. The LZTFL1 gene is a part of a transcriptional map covering 250 kb within the common eliminated region 1 (C3CER1) in 3p21.3. Kiss, H., Kedra, D., Kiss, C., Kost-Alimova, M., Yang, Y., Klein, G., Imreh, S., Dumanski, J.P. Genomics (2001) [Pubmed]
  5. A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. Kiss, H., Kedra, D., Yang, Y., Kost-Alimova, M., Kiss, C., O'Brien, K.P., Fransson, I., Klein, G., Imreh, S., Dumanski, J.P. Hum. Genet. (1999) [Pubmed]
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