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Gene Review

CER1  -  cerberus 1, DAN family BMP antagonist

Homo sapiens

Synonyms: Cerberus, Cerberus-related protein, DAN domain family member 4, DAND4
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Disease relevance of CER1

  • A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors [1].
  • CONCLUSIONS: FGFR1 (exon 7), CER1, and CDON are not related to trigonocephaly in our sample and should not be considered as causative genes for metopic synostosis [2].

High impact information on CER1

  • However, very efficient down-regulation of the EGF receptor occurred in CER-1 cells [3].
  • One variant isolated from Ca9-22 cells, CER-1, grew without being affected by EGF [3].
  • The EGF receptors on both Ca9-22 and CER-1 cells were autophosphorylated upon EGF exposure in a similar manner suggesting no obvious alteration in receptor tyrosine kinase [3].
  • We have found previously that during tumor growth intact human chromosome 3 transferred into tumor cells regularly looses certain 3p regions, among them the approximately 1.4-Mb common eliminated region 1 (CER1) at 3p21 [4].
  • Surprisingly, we detected three regions that were lost in all or majority of tumors: CER1 (3p21.3, Mb: 43.32-45.74), CER2 (3p22, Mb: 37.83-39.06) and FER (3p14.3-p21.2, Mb: 50.12-58.03) [5].

Biological context of CER1


Anatomical context of CER1

  • CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells [8].

Associations of CER1 with chemical compounds

  • In the present study, small-angle X-ray diffraction was used to examine the organization in synthetic lipid mixtures of which the synthetic ceramide fraction was prepared with sphingosine-based CER1 or phytosphingosine-based CER9 [9].
  • Only a mixture containing synthetic CER1 and CER3, CHOL and FFA showed similar phase behaviour to that of SC [10].
  • The main lipid classes in SC are cholesterol (CHOL), free fatty acids (FFA) and at least nine classes of ceramides (CER), referred to as CER1 to CER9 [10].

Physical interactions of CER1

  • Three TCF/LEF-binding sites within human CER1 promoter were conserved in chimpanzee CER1 promoter, two in cow and dog Cer1 promoters, but not in rodent Cer1 promoters [8].

Other interactions of CER1


Analytical, diagnostic and therapeutic context of CER1

  • 3. Fluorescence in situ hybridization analysis of 12 mouse orthologous loci revealed that CER1 splits into two segments in mouse and therefore contains a murine/human conservation breakpoint region (CBR) [4].


  1. A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors. Yang, Y., Kiss, H., Kost-Alimova, M., Kedra, D., Fransson, I., Seroussi, E., Li, J., Szeles, A., Kholodnyuk, I., Imreh, M.P., Fodor, K., Hadlaczky, G., Klein, G., Dumanski, J.P., Imreh, S. Genomics (1999) [Pubmed]
  2. Mutational screening of FGFR1, CER1, and CDON in a large cohort of trigonocephalic patients. Jehee, F.S., Alonso, L.G., Cavalcanti, D.P., Kim, C., Wall, S.A., Mulliken, J.B., Sun, M., Jabs, E.W., Boyadjiev, S.A., Wilkie, A.O., Passos-Bueno, M.R. Cleft Palate Craniofac. J. (2006) [Pubmed]
  3. Two independent mechanisms for escaping epidermal growth factor-mediated growth inhibition in epidermal growth factor receptor-hyperproducing human tumor cells. Hirai, M., Gamou, S., Minoshima, S., Shimizu, N. J. Cell Biol. (1988) [Pubmed]
  4. Coincidence of synteny breakpoints with malignancy-related deletions on human chromosome 3. Kost-Alimova, M., Kiss, H., Fedorova, L., Yang, Y., Dumanski, J.P., Klein, G., Imreh, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Modeling non-random deletions in cancer. Kost-Alimova, M., Imreh, S. Semin. Cancer Biol. (2007) [Pubmed]
  6. Interstitial deletions including chromosome 3 common eliminated region 1 (C3CER1) prevail in human solid tumors from 10 different tissues. Petursdottir, T.E., Thorsteinsdottir, U., Jonasson, J.G., Moller, P.H., Huiping, C., Bjornsson, J., Egilsson, V., Imreh, S., Ingvarsson, S. Genes Chromosomes Cancer (2004) [Pubmed]
  7. Human cerberus related gene CER1 maps to chromosome 9. Lah, M., Brodnicki, T., Maccarone, P., Nash, A., Stanley, E., Harvey, R.P. Genomics (1999) [Pubmed]
  8. CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. Katoh, M., Katoh, M. Int. J. Mol. Med. (2006) [Pubmed]
  9. Acylceramide head group architecture affects lipid organization in synthetic ceramide mixtures. de Jager, M., Gooris, G., Ponec, M., Bouwstra, J. J. Invest. Dermatol. (2004) [Pubmed]
  10. The phase behaviour of skin lipid mixtures based on synthetic ceramides. de Jager, M.W., Gooris, G.S., Dolbnya, I.P., Bras, W., Ponec, M., Bouwstra, J.A. Chem. Phys. Lipids (2003) [Pubmed]
  11. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. Katoh, M., Katoh, M. Oncol. Rep. (2004) [Pubmed]
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