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OSBP2  -  oxysterol binding protein 2

Homo sapiens

Synonyms: HLM, KIAA1664, ORP-4, ORP4, OSBP-related protein 4, ...
 
 
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Disease relevance of OSBP2

 

High impact information on OSBP2

  • Orp4p is essential for viability of Sc. pombe and is expressed throughout the cell cycle [2].
  • The Orp4 protein (and its isolated N-terminal domain) binds to the Sc. pombe replication origin, ars1 [2].
  • OSBP1 is located in chromosome 11q12.1, and OSBP2 is located in 22q12 [3].
  • Western blot analysis using peptide antibodies specific to OSBP1 and OSBP2 detected the proteins in different subcellular fractions in the retinal monkey tissue [3].
  • OSBP1 is detected mainly in the soluble or cytosolic fraction and nuclei whereas OSBP2 is detected exclusively in the detergent soluble fraction suggesting association with membranes [3].
 

Anatomical context of OSBP2

  • In this study we focused on the evaluation of HLM/OSBP2 expression in malignant cell lines from different origins (blood and solid tumors) and we also evaluated its expression in chronic myeloid leukemia patients, correlating the molecular findings with clinical outcome [1].
 

Other interactions of OSBP2

  • In addition to OSBP and the recently reported OSBP2, we have found 10 other genes encoding oxysterol-binding domains [4].

References

  1. HLM/OSBP2 is expressed in chronic myeloid leukemia. Henriques Silva, N., Vasconcellos Fournier, M., Pimenta, G., Pulcheri, W.A., Spector, N., da Costa Carvalho, M.d.a. .G. Int. J. Mol. Med. (2003) [Pubmed]
  2. The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. Chuang, R.Y., Kelly, T.J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina. Moreira, E.F., Jaworski, C., Li, A., Rodriguez, I.R. J. Biol. Chem. (2001) [Pubmed]
  4. A family of 12 human genes containing oxysterol-binding domains. Jaworski, C.J., Moreira, E., Li, A., Lee, R., Rodriguez, I.R. Genomics (2001) [Pubmed]
 
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