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Gene Review

BCL2L13  -  BCL2-like 13 (apoptosis facilitator)

Homo sapiens

Synonyms: BCL-RAMBO, Bcl-2-like protein 13, Bcl-rambo, Bcl2-L-13, CD003, ...
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High impact information on BCL2L13

  • Thus, Bcl-rambo constitutes a novel type of pro-apoptotic Bcl-2 member that triggers cell death independently of its BH motifs [1].
  • In mammalian cells, Bcl-rambo was localized to mitochondria, and its overexpression induces apoptosis that is specifically blocked by the caspase inhibitors, IAPs, whereas inhibitors controlling upstream events of either the 'death receptor' (FLIP, FADD-DN) or the 'mitochondrial' pro-apoptotic pathway (Bcl-x(L)) had no effect [1].
  • Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension [1].
  • No interaction of Bcl-rambo with either anti-apoptotic (Bcl-2, Bcl-x(L), Bcl-w, A1, MCL-1, E1B-19K, and BHRF1) or pro-apoptotic (Bax, Bak, Bik, Bid, Bim, and Bad) members of the Bcl-2 family was observed [1].
  • Here, we report the presence of a special splicing variant of a proapoptotic protein Bcl-rambo in human lymph node, designated as Bcl-rambo beta [2].

Anatomical context of BCL2L13


Associations of BCL2L13 with chemical compounds


  1. Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. Kataoka, T., Holler, N., Micheau, O., Martinon, F., Tinel, A., Hofmann, K., Tschopp, J. J. Biol. Chem. (2001) [Pubmed]
  2. Bcl-rambo beta, a special splicing variant with an insertion of an Alu-like cassette, promotes etoposide- and Taxol-induced cell death. Yi, P., Zhang, W., Zhai, Z., Miao, L., Wang, Y., Wu, M. FEBS Lett. (2003) [Pubmed]
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