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Gene Review:

Svs1 - seminal vesicle secretory protein 1

Mus musculus

Synonyms: SVS I

Lai, M.L. et al., Veselský, L. et al., Dostál, J. et al., Yu, L.C. et al., Huang, Y.H. et al., et al.

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High impact information on Svs1

SVS VII, one of seven major proteins in mouse seminal vesicle secretion, was purified to homogeneity [1].
Seminal vesicle autoantigen (SVA) is a 19 kDa glycoprotein purified from mouse seminal vesicle secretion [2].
Primary structure and characterization of an androgen-stimulated autoantigen purified from mouse seminal-vesicle secretion [3].
Repeated i.p. or rectal treatment of male and female mice with an immunosuppressive component isolated from boar seminal vesicle secretion reduced responses of B lymphocytes to mitogen as evaluated by [3H]thymidine or bromo-deoxyuridine incorporation [4].
Intravenous deposition of the immunosuppressive component, isolated from boar seminal vesicle secretion, led to suppression of primary and secondary antibody response to boar epididymal spermatozoa and to bacterial antigens [5].

Associations of Svs1 with chemical compounds

A Kazal-type trypsin inhibitor in mouse seminal vesicle secretion was purified to homogeneity via a series of purification steps including ammonium sulfate fractionation, affinity chromatography on a trypsin Affi-Gel 10 column, and HPLC on a reverse phase C4 column [6].

References

A novel heat-labile phospholipid-binding protein, SVS VII, in mouse seminal vesicle as a sperm motility enhancer. Luo, C.W., Lin, H.J., Chen, Y.H. J. Biol. Chem. (2001) [Pubmed]
Seminal vesicle autoantigen, a novel phospholipid-binding protein secreted from luminal epithelium of mouse seminal vesicle, exhibits the ability to suppress mouse sperm motility. Huang, Y.H., Chu, S.T., Chen, Y.H. Biochem. J. (1999) [Pubmed]
Primary structure and characterization of an androgen-stimulated autoantigen purified from mouse seminal-vesicle secretion. Yu, L.C., Chen, J.L., Tsai, W.B., Chen, Y.H. Biochem. J. (1993) [Pubmed]
Effect of boar seminal immunosuppressive fraction on B lymphocytes and on primary antibody response. Veselský, L., Dostál, J., Holán, V., Soucek, J., Zelezná, B. Biol. Reprod. (1996) [Pubmed]
Inhibition of bacterial and boar epididymal sperm immunogenicity by boar seminal immunosuppressive component in mice. Dostál, J., Veselský, L., Marounek, M., Zelezná, B., Jonáková, V. J. Reprod. Fertil. (1997) [Pubmed]
Purification and characterization of a trypsin inhibitor from mouse seminal vesicle secretion. Lai, M.L., Chen, S.W., Chen, Y.H. Arch. Biochem. Biophys. (1991) [Pubmed]

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