Gene Review:
Zfp128 - zinc finger protein 128
Mus musculus
Synonyms:
9630016P15Rik, Znf8, mZnf8
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High impact information on Zfp128
- Our data support the hypothesis that mZnf8 plays critical roles in mediating BMP signaling during spermatogenesis [1].
- A novel mouse Krüppel-type zinc finger protein, mZnf8, was isolated [1].
- Transcription of mZnf8 is ubiquitous in mouse embryos, but high levels are specifically observed in adult mouse testes, with the same cell- and stage-specific transcription pattern as Smad1 [1].
- Interactions between mZnf8 and Smad proteins were further analyzed with various in vitro and in vivo approaches, including mammalian two-hybrid, in vitro glutathione S-transferase pulldown, and copurification assays [1].
Biological context of Zfp128
- Silencing the expression of endogenous mZnf8 with an RNA interference approach caused a significant increase in the expression of one BMP reporter [1].
References
- Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Jiao, K., Zhou, Y., Hogan, B.L. Mol. Cell. Biol. (2002) [Pubmed]
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