Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Defb8 - defensin beta 8

Mus musculus

Synonyms: BD-8, Beta-defensin 8, Defensin, beta 8, Defensin-related peptide, Defr1, ...

Morrison, G.M. et al., Maxwell, A.I. et al., Ouellette, A.J. et al., Ouellette, A.J. et al., Clarke, D.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Defb8

A synthetic Defr1 peptide displayed antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Burkholderia cepacia [1].
The antimicrobial activity of Defr1 against S. aureus, E. coli and B. cepacia was found to be reduced in raised concentration of NaCl, but its action against P. aeruginosa was independent of NaCl concentration [2].

High impact information on Defb8

Cryptdin mRNA codes for the apparent precursor to a corticostatin/defensin-related peptide that accumulates to high levels in mouse intestinal crypt epithelium during postnatal development [3].
This defensin-related gene (Defr1) is most highly expressed in testis and heart [1].
We present our structural and functional studies of a novel mouse beta-defensin-related peptide (Defr1) which contains only five cysteine residues [4].

Anatomical context of Defb8

Cryptdin is a defensin-related peptide, and its mRNA accumulates to high abundance in epithelial cells of intestinal crypts beginning in the second week of postnatal development [5].

References

Identification and characterization of a novel murine beta-defensin-related gene. Morrison, G.M., Rolfe, M., Kilanowski, F.M., Cross, S.H., Dorin, J.R. Mamm. Genome (2002) [Pubmed]
Rapid sequence divergence in mammalian beta-defensins by adaptive evolution. Maxwell, A.I., Morrison, G.M., Dorin, J.R. Mol. Immunol. (2003) [Pubmed]
Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. Ouellette, A.J., Greco, R.M., James, M., Frederick, D., Naftilan, J., Fallon, J.T. J. Cell Biol. (1989) [Pubmed]
Structural and functional studies of defensin-inspired peptides. Clarke, D.J., Campopiano, D.J. Biochem. Soc. Trans. (2006) [Pubmed]
Localization of the cryptdin locus on mouse chromosome 8. Ouellette, A.J., Pravtcheva, D., Ruddle, F.H., James, M. Genomics (1989) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg