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Gene Review

Defb8  -  defensin beta 8

Mus musculus

Synonyms: BD-8, Beta-defensin 8, Defensin, beta 8, Defensin-related peptide, Defr1, ...
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Disease relevance of Defb8


High impact information on Defb8

  • Cryptdin mRNA codes for the apparent precursor to a corticostatin/defensin-related peptide that accumulates to high levels in mouse intestinal crypt epithelium during postnatal development [3].
  • This defensin-related gene (Defr1) is most highly expressed in testis and heart [1].
  • We present our structural and functional studies of a novel mouse beta-defensin-related peptide (Defr1) which contains only five cysteine residues [4].

Anatomical context of Defb8


  1. Identification and characterization of a novel murine beta-defensin-related gene. Morrison, G.M., Rolfe, M., Kilanowski, F.M., Cross, S.H., Dorin, J.R. Mamm. Genome (2002) [Pubmed]
  2. Rapid sequence divergence in mammalian beta-defensins by adaptive evolution. Maxwell, A.I., Morrison, G.M., Dorin, J.R. Mol. Immunol. (2003) [Pubmed]
  3. Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium. Ouellette, A.J., Greco, R.M., James, M., Frederick, D., Naftilan, J., Fallon, J.T. J. Cell Biol. (1989) [Pubmed]
  4. Structural and functional studies of defensin-inspired peptides. Clarke, D.J., Campopiano, D.J. Biochem. Soc. Trans. (2006) [Pubmed]
  5. Localization of the cryptdin locus on mouse chromosome 8. Ouellette, A.J., Pravtcheva, D., Ruddle, F.H., James, M. Genomics (1989) [Pubmed]
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