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Gene Review

Hbb  -  hemoglobin, beta

Rattus norvegicus

Synonyms: Beta-1-globin, Hemoglobin beta chain, major-form, Hemoglobin beta-1 chain, Hemoglobin subunit beta-1
 
 
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Disease relevance of Hbb

  • However, no linkage between Hbb and Tls-1 loci could be demonstrated since WKY rats also developed a high incidence of thymic lymphomas in response to PNU [1].
  • Cramer (1981) reported that Pg-1 (urinary pepsinogen) in the rat was loosely linked with albinism in the linkage group I. We performed a three point test on the loci of pg-1, c, and Hbb [2].
 

High impact information on Hbb

  • Furthermore, all the amino acid replacements correspond to single point DNA mutations and (with the exception of the substitution Asp 22-->Asn in the beta 2-globin) involve uncharged substitutions [3].
  • The calculated distances of Acon-1 to c and Hbb are 30.1 +/- 5.0 and 36.1 +/- 5.3 cM, respectively [4].
  • The distances of Lap-1 to c, RT6, and Hbb, based on recombination frequencies, are 3.1 +/- 1.5, 8.3 +/- 4.0, and 11.4 +/- 2.8 cM, respectively [4].
  • A major locus (Dpg) with two alleles (d and D) controls erythrocyte 2,3-diphosphoglycerate (DPG) levels in Long-Evans rats and is closely linked to a locus (Hbb) determining a hemoglobin electrophoretic polymorphism [5].
  • Close linkage of peripheral T-lymphocyte antigen A (PtaA) to the hemoglobin variant Hbb on linkage group I of the rat [6].

References

  1. Genetic regulation of development of thymic lymphomas induced by N-propyl-N-nitrosourea in the rat. Ogiu, T., Fukami, H., Nishimura, M., Matsuyama, M. Jpn. J. Cancer Res. (1995) [Pubmed]
  2. Polymorphism in Pg-1 (urinary pepsinogen-1) locus in the rat and its linkage analysis. Kondo, Y., Yamada, J. Jikken Dobutsu (1983) [Pubmed]
  3. Mass spectrometric analysis of rat hemoglobin by FAB-overlapping. Primary structure of the alpha-major and of four beta constitutive chains. Ferranti, P., Carbone, V., Sannolo, N., Fiume, I., Malorni, A. Int. J. Biochem. (1993) [Pubmed]
  4. Assignment of Lap-1 to linkage group I of the rat (Rattus norvegicus). van Zutphen, L.F., den Bieman, M., Hedrich, H.J., Kluge, R. Biochem. Genet. (1985) [Pubmed]
  5. Erythrocyte isozymes of phosphofructokinase in genetically high- and low-2,3-diphosphoglycerate rats. Noble, N.A., Kuwashima, L.H., Togioka, T.T., Tanaka, K.R. Biochem. Genet. (1982) [Pubmed]
  6. Close linkage of peripheral T-lymphocyte antigen A (PtaA) to the hemoglobin variant Hbb on linkage group I of the rat. Butcher, G.W., Clarke, S., Tucker, E.M. Transplant. Proc. (1979) [Pubmed]
 
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