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MeSH Review

Rats, Long-Evans

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Disease relevance of Rats, Long-Evans


Psychiatry related information on Rats, Long-Evans


High impact information on Rats, Long-Evans

  • To investigate whether leptin exerts similar effects in normal animals, we administered leptin intracerebroventricularly (icv) to Long-Evans rats [11].
  • Further studies in Long-Evans rats demonstrate a similar response to a comparable degree of fluid deprivation as Uosm and AVP mRNA were significantly increased after 72 h of fluid deprivation (Uosm, 1,505 +/- 186 to 5,460 +/- 560 mosmol/kg, P less than 0.001; AVP mRNA, 31.7 +/- 3.9 to 77.5 +/- 4.6 pg/micrograms total RNA, P less than 0.001) [12].
  • Chromosomes obtained from tumors in male Long-Evans rats with transplantable Shay chloroleukemia were counted and analyzed with Giemsa staining and quinacrine fluorescence [13].
  • Concentrations of PKC were determined for individual 6-month-old (n = 13) and 24-month-old (n = 27) male Long-Evans rats trained in the water maze on a standard place-learning task and a transfer task designed for rapid acquisition [14].
  • Adult Long Evans rats were maintained on ethanol-containing or isocaloric control liquid diets for 8 weeks, after which the livers were harvested to measure mRNA levels, protein expression, and kinase or phosphatase activity related to survival or proapoptosis mechanisms [15].

Chemical compound and disease context of Rats, Long-Evans


Biological context of Rats, Long-Evans


Anatomical context of Rats, Long-Evans


Associations of Rats, Long-Evans with chemical compounds

  • First, young adult or mid-aged male Long-Evans rats were treated for either 1 or 3 months with corticosterone, at a dose sufficient to mimic the elevated hormone levels observed following exposure to mild stress [30].
  • To investigate the ability of different hormonal agents to block the effects of cyclophosphamide (CTX) on reproductive function, sexually mature female Long-Evans rats were studied [31].
  • Diabetes was induced in Long-Evans rats with streptozotocin, and simvastatin administration was begun immediately after the induction of diabetes [32].
  • These parameters plus luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were studied in experiments 2 and 3 with Long-Evans rats in untreated diabetic, control, insulin-treated diabetic, nondiabetic STZ-injected, and semistarved groups [27].
  • Cotreatment of male Long Evans rats with MCDF (50 mumol/kg) and a dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) that causes a near-maximal induction of hepatic microsomal aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase activities resulted in a significant inhibition of these activities for up to 96 hr [33].

Gene context of Rats, Long-Evans

  • 1. In conscious, Long Evans rats, chronically instrumented for the measurement of regional haemodynamics, we compared responses to the putative, selective ETB-receptor agonist, [Ala1,3,11,15]endothelin-1 (ET-1), obtained from two sources (Microchemical Laboratory, Cambridge (MLC) and Neosystem Laboratory, France (NLF)) [34].
  • The localization of CRF-41 related peptide was studied in the brain and posterior pituitary of the homozygous rats for the inherited diabetes insipidus (Brattleboro strain, DI) and of the Long-Evans rats (LE) as control [35].
  • These studies demonstrate that the cytokine responses in Long-Evans rats exposed to a superantigen are somewhat similar to those that occur in mice and humans, e.g. a rapid short increase in the production of IFN-gamma and TNF that was accompanied by an increase in the production of IL-2 [36].
  • Satiated Long-Evans rats with temperature transponders implanted in the interscapular brown adipose tissue (BAT) displayed a dose-dependent decrease in BAT temperature and an increase in food intake after ICV infusion of NPY [37].
  • Rat synthetic amidated islet amyloid polypeptide (IAPP) was infused into conscious Long-Evans rats chronically instrumented for the measurement of regional hemodynamics [38].

Analytical, diagnostic and therapeutic context of Rats, Long-Evans


  1. Involvement of chromosome No. 2 in chromosome changes in primary leukemia induced in rats by N-nitroso-N-butylurea. Uenaka, H., Ueda, N., Maeda, S., Sugiyama, T. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Ultrastructure of spontaneous and urethan-induced thymomas in buffalo rats. Matsuyama, M., Suzuki, H., Yamada, S., Ito, M., Nagayo, T. Cancer Res. (1975) [Pubmed]
  3. Studies on the beneficial effects of aspirin in endotoxic shock. Relationship to inhibition of arachidonic acid metabolism. Halushka, P.V., Wise, W.C., Cook, J.A. Am. J. Med. (1983) [Pubmed]
  4. Enkephalin effects on blood pressure, heart rate, and baroreceptor reflex. Schaz, K., Stock, G., Simon, W., Schlör, K.H., Unger, T., Rockhold, R., Ganten, D. Hypertension (1980) [Pubmed]
  5. Role of vasopressin in cardiovascular response to central cholinergic stimulation in rats. Imai, Y., Abe, K., Sasaki, S., Minami, N., Munakata, M., Yumita, S., Nobunaga, T., Sekino, H., Yoshinaga, K. Hypertension (1989) [Pubmed]
  6. Reentrainment of rat circadian activity rhythms: effects of melatonin. Redman, J.R., Armstrong, S.M. J. Pineal Res. (1988) [Pubmed]
  7. Differential rates of glucose metabolism across subregions of the subfornical organ in Brattleboro rats. Shaver, S.W., Kadekaro, M., Gross, P.M. Regul. Pept. (1990) [Pubmed]
  8. Induction of maternal behavior in rats: effects of pseudopregnancy termination and placenta-smeared pups. Steuer, M.A., Thompson, A.C., Doerr, J.C., Youakim, M., Kristal, M.B. Behav. Neurosci. (1987) [Pubmed]
  9. Different functions of rat's pedunculopontine tegmental nucleus are reflected in cortical EEG. Bringmann, A. Neuroreport (1995) [Pubmed]
  10. Changes in self-stimulation at stimulation-bound eating and drinking sites in the lateral hypothalamus during food or water deprivation, glucoprivation, and intracellular or extracellular dehydration. Frutiger, S.A. Behav. Neurosci. (1986) [Pubmed]
  11. Identification of targets of leptin action in rat hypothalamus. Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P., Baskin, D.G. J. Clin. Invest. (1996) [Pubmed]
  12. Arginine vasopressin gene regulation in the homozygous Brattleboro rat. Kim, J.K., Soubrier, F., Michel, J.B., Bankir, L., Corvol, P., Schrier, R.W. J. Clin. Invest. (1990) [Pubmed]
  13. Chromosome studies of the transplantable Shay chloroleukemia in rats. Alt, B. J. Natl. Cancer Inst. (1977) [Pubmed]
  14. Spatial memory is related to hippocampal subcellular concentrations of calcium-dependent protein kinase C isoforms in young and aged rats. Colombo, P.J., Wetsel, W.C., Gallagher, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  15. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Yeon, J.E., Califano, S., Xu, J., Wands, J.R., De La Monte, S.M. Hepatology (2003) [Pubmed]
  16. Role of vasopressin in neurocardiogenic responses to hemorrhage in conscious rats. Imai, Y., Kim, C.Y., Hashimoto, J., Minami, N., Munakata, M., Abe, K. Hypertension (1996) [Pubmed]
  17. Pressor action of centrally perfused angiotensin II in rats with hereditary hypothalamic diabetes insipidus. Hutchinson, J.S., Schelling, P., Möhring, J., Ganten, D. Endocrinology (1976) [Pubmed]
  18. Nascent hepatic lipoproteins in hypothyroid rats. Dolphin, P.J., Forsyth, S.J. J. Lipid Res. (1983) [Pubmed]
  19. Selective effects of neonatal hypothyroidism on monoamine oxidase activities in the rat brain. Vaccari, A., Biassoni, R., Timiras, P.S. J. Neurochem. (1983) [Pubmed]
  20. Differential cardiovascular effects of centrally administered vasopressin in conscious Long Evans and Brattleboro rats. Harland, D., Gardiner, S.M., Bennett, T. Circ. Res. (1989) [Pubmed]
  21. The contribution of vasopressin and angiotensin to the maintenance of blood pressure after autonomic blockade. Hiwatari, M., Nolan, P.L., Johnston, C.I. Hypertension (1985) [Pubmed]
  22. Failure of clorazepate to cause malformations or fetal wastage in the rat. Corwin, H., DeMyer, W. Arch. Neurol. (1980) [Pubmed]
  23. Effects of age on pilocarpine-induced c-fos expression in rat hippocampus and cortex. Bucci, D.J., Rosen, D.L., Gallagher, M. Neurobiol. Aging (1998) [Pubmed]
  24. Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene. Kano, T., Abe, T., Tomita, H., Sakata, T., Ishiguro, S., Tamai, M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  25. Differential effects of dorsal and ventral hippocampal lesions. Hock, B.J., Bunsey, M.D. J. Neurosci. (1998) [Pubmed]
  26. Specificity of circadian function in transplants of the fetal suprachiasmatic nucleus. Earnest, D.J., Sladek, C.D., Gash, D.M., Wiegand, S.J. J. Neurosci. (1989) [Pubmed]
  27. Primary hypoandrogenism in experimental diabetes in the Long-Evans rat. Anderson, J.E., Jones, D., Penner, S.B., Thliveris, J.A. Diabetes (1987) [Pubmed]
  28. Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats. Fong, Y., Edelstein, D., Wang, E.A., Brownlee, M. Diabetologia (1993) [Pubmed]
  29. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibers in cerebral arteries. Nozaki, K., Moskowitz, M.A., Maynard, K.I., Koketsu, N., Dawson, T.M., Bredt, D.S., Snyder, S.H. J. Cereb. Blood Flow Metab. (1993) [Pubmed]
  30. Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. Bodnoff, S.R., Humphreys, A.G., Lehman, J.C., Diamond, D.M., Rose, G.M., Meaney, M.J. J. Neurosci. (1995) [Pubmed]
  31. Gonadal protection and fecundity rates in cyclophosphamide-treated rats. Montz, F.J., Wolff, A.J., Gambone, J.C. Cancer Res. (1991) [Pubmed]
  32. Simvastatin inhibits leukocyte accumulation and vascular permeability in the retinas of rats with streptozotocin-induced diabetes. Miyahara, S., Kiryu, J., Yamashiro, K., Miyamoto, K., Hirose, F., Tamura, H., Katsuta, H., Nishijima, K., Tsujikawa, A., Honda, Y. Am. J. Pathol. (2004) [Pubmed]
  33. Partial antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated induction of aryl hydrocarbon hydroxylase by 6-methyl-1,3,8-trichlorodibenzofuran: mechanistic studies. Harris, M., Zacharewski, T., Astroff, B., Safe, S. Mol. Pharmacol. (1989) [Pubmed]
  34. Effects of an ET1-receptor antagonist, FR139317, on regional haemodynamic responses to endothelin-1 and [Ala11,15]Ac-endothelin-1 (6-21) in conscious rats. Gardiner, S.M., Kemp, P.A., March, J.E., Bennett, T., Davenport, A.P., Edvinsson, L. Br. J. Pharmacol. (1994) [Pubmed]
  35. Comparative immunocytochemical localization of corticotropin releasing factor (CRF-41) and neurohypophysial peptides in the brain of Brattleboro and Long-Evans rats. Burlet, A., Tonon, M.C., Tankosic, P., Coy, D., Vaudry, H. Neuroendocrinology (1983) [Pubmed]
  36. Superantigen activation and kinetics of cytokines in the Long-Evans rat. Huang, W., Koller, L.D. Immunology (1998) [Pubmed]
  37. Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Hwa, J.J., Witten, M.B., Williams, P., Ghibaudi, L., Gao, J., Salisbury, B.G., Mullins, D., Hamud, F., Strader, C.D., Parker, E.M. Am. J. Physiol. (1999) [Pubmed]
  38. Antagonistic effect of human alpha-calcitonin gene-related peptide (8-37) on regional hemodynamic actions of rat islet amyloid polypeptide in conscious Long-Evans rats. Gardiner, S.M., Compton, A.M., Kemp, P.A., Bennett, T., Bose, C., Foulkes, R., Hughes, B. Diabetes (1991) [Pubmed]
  39. Blunted pressure natriuresis in the Brattleboro diabetes insipidus rat. Gonzalez-Campoy, J.M., Awazu, M., Granger, J.P., Haas, J.A., Romero, J.C., Knox, F.G. Hypertension (1989) [Pubmed]
  40. PKC-beta inhibitor (LY333531) attenuates leukocyte entrapment in retinal microcirculation of diabetic rats. Nonaka, A., Kiryu, J., Tsujikawa, A., Yamashiro, K., Miyamoto, K., Nishiwaki, H., Honda, Y., Ogura, Y. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
  41. Cartilage sulfation and serum somatomedin in rats during and after cortisone-induced growth arrest. Mosier, H.D., Jansons, R.A., Hill, R.R., Dearden, L.C. Endocrinology (1976) [Pubmed]
  42. Polypeptide patterns of hepatic microsomes from Long-Evans rats treated with different xenobiotics. Vlasuk, G.P., Ryan, D.E., Thomas, P.E., Levin, W., Walz, F.G. Biochemistry (1982) [Pubmed]
  43. Long-term effects of light damage on the retina of albino and pigmented rats. Wasowicz, M., Morice, C., Ferrari, P., Callebert, J., Versaux-Botteri, C. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
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