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Gene Review

Ibsp  -  integrin-binding sialoprotein

Rattus norvegicus

Synonyms: BSP II, Bone sialoprotein 2, Bone sialoprotein II, Cell-binding sialoprotein, Integrin-binding sialoprotein
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Disease relevance of Ibsp

  • Interestingly, the vitamin D deficiency also did not have dramatic effects on several bone cell-derived noncollagenous proteins including: bone proteoglycans I & II, bone sialoprotein II osteonectin, and osteocalcin [1].

High impact information on Ibsp

  • The DE implant evoked an accelerated mRNA expression for osteonectin and osteocalcin compared with the turned Implant, along with an up-regulated expression for bone sialoprotein II, collagen III, and integrins in initial healing stages up to week 1 [2].
  • Our in situ phosphorylation experiments done with [gamma-32P] GTP suggest the existence of extracellular phosphorylation by a casein kinase II (CKII)-like enzyme, the enzyme known to phosphorylate most of the phosphate residues in dentin phosphophoryn and bone sialoproteins (osteopontin and BSP II) [3].
  • Amino acid analysis showed that the UM I glycoconjugate was rich in acidic amino acids (12.6% aspartic acid and 21.2% glutamic acid residues) and its N-terminal sequence was Phe-Ser-Met-Lys-Asn-Phe-, which is identical to the published N-terminal amino acid sequence of rat bone sialoprotein II [4].
  • At this time some cells were negative for these cartilage markers, but positive for osteoblast markers, bone sialoprotein II, osteocalcin and type I collagen [5].


  1. Noncollagenous bone proteins in experimental rickets in the rat. Wientroub, S., Fisher, L.W., Reddi, A.H., Termine, J.D. Mol. Cell. Biochem. (1987) [Pubmed]
  2. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. Ogawa, T., Nishimura, I. The International journal of oral & maxillofacial implants. (2003) [Pubmed]
  3. Extracellular processing of bone and dentin proteins in matrix mineralization. Suzuki, Y., Kubota, T., Koizumi, T., Satoyoshi, M., Teranaka, T., Kawase, T., Ikeda, T., Yamaguchi, A., Saito, S., Mikuni-Takagaki, Y. Connect. Tissue Res. (1996) [Pubmed]
  4. Further purification and characterization of newly synthesized anionic glycoconjugates secreted by cultured UMR-106 cells: evidence that the major anionic glycoconjugate secreted by these cells is similar to bone sialoprotein II. Chopra, R.K., Anastassiades, T.P., Lohnes, D., Jones, G. Biochem. Cell Biol. (1991) [Pubmed]
  5. Formation of chondrous and osseous tissues in micromass cultures of rat frontonasal and mandibular ectomesenchyme. Langille, R.M., Solursh, M. Differentiation (1990) [Pubmed]
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