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Gene Review

Sparc  -  secreted protein, acidic, cysteine-rich...

Rattus norvegicus

Synonyms: BM-40, Basement-membrane protein 40, ON, Osteonectin, SPARC, ...
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Disease relevance of Sparc


High impact information on Sparc


Chemical compound and disease context of Sparc


Biological context of Sparc


Anatomical context of Sparc


Associations of Sparc with chemical compounds

  • Regional differences in expression of osteonectin mRNA after administration of cadmium to rats [1].
  • Dexamethasone (Dex) treatment caused a dose-dependent increase in osteonectin mRNA, half maximally effective between 1 nM and 10 nM Dex [14].
  • The osteonectin-degrading activity was further characterized and found to be optimally active between pH 6 and 8 and inhibited with EDTA and 1, 10-phenanthroline but not phenylmethylsulfonyl fluoride [15].
  • Comparison of the binding properties of this cleavage product with intact osteonectin indicated that the fragment retained its ability to bind hydroxyapatite in the presence of high salt (2 M NaCl) [15].
  • Both ramipril and valsartan ameliorated renal injury and significantly reduced SPARC overexpression in the STNx animals [16].

Other interactions of Sparc


Analytical, diagnostic and therapeutic context of Sparc


  1. Regional differences in expression of osteonectin mRNA after administration of cadmium to rats. Lee, M.J., Saijoh, K., Nestler, E.J., Duman, R.S., Sumino, K. Arch. Toxicol. (1995) [Pubmed]
  2. SPARC is expressed by mesangial cells in experimental mesangial proliferative nephritis and inhibits platelet-derived-growth-factor-medicated mesangial cell proliferation in vitro. Pichler, R.H., Bassuk, J.A., Hugo, C., Reed, M.J., Eng, E., Gordon, K.L., Pippin, J., Alpers, C.E., Couser, W.G., Sage, E.H., Johnson, R.J. Am. J. Pathol. (1996) [Pubmed]
  3. Increased SPARC expression promotes U87 glioblastoma invasion in vitro. Golembieski, W.A., Ge, S., Nelson, K., Mikkelsen, T., Rempel, S.A. Int. J. Dev. Neurosci. (1999) [Pubmed]
  4. SPARC-like 1 regulates the terminal phase of radial glia-guided migration in the cerebral cortex. Gongidi, V., Ring, C., Moody, M., Brekken, R., Sage, E.H., Rakic, P., Anton, E.S. Neuron (2004) [Pubmed]
  5. Molecular cloning of SC1: a putative brain extracellular matrix glycoprotein showing partial similarity to osteonectin/BM40/SPARC. Johnston, I.G., Paladino, T., Gurd, J.W., Brown, I.R. Neuron (1990) [Pubmed]
  6. SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts. Mettouchi, A., Cabon, F., Montreau, N., Vernier, P., Mercier, G., Blangy, D., Tricoire, H., Vigier, P., Binétruy, B. EMBO J. (1994) [Pubmed]
  7. Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations. Wrana, J.L., Maeno, M., Hawrylyshyn, B., Yao, K.L., Domenicucci, C., Sodek, J. J. Cell Biol. (1988) [Pubmed]
  8. Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. Maeng, H.Y., Choi, D.K., Takeuchi, M., Yamamoto, M., Tominaga, M., Tsukamoto, T., Tatematsu, M., Ito, T., Sakaki, Y., Furihata, C. Jpn. J. Cancer Res. (2002) [Pubmed]
  9. Expression of SPARC (secreted protein, acidic and rich in cysteine) in healing intestinal anastomoses and short bowel syndrome in rats. Puolakkainen, P., Reed, M., Vento, P., Sage, E.H., Kiviluoto, T., Kivilaakso, E. Dig. Dis. Sci. (1999) [Pubmed]
  10. Purification of a calcium binding protein (rat SPARC) from primary Sertoli cell-enriched culture medium. Cheng, C.Y. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  11. Regulation of collagen type I and biglycan mRNA levels by hormones and growth factors in normal and immortalized osteoblastic cell lines. Thiébaud, D., Guenther, H.L., Porret, A., Burckhardt, P., Fleisch, H., Hofstetter, W. J. Bone Miner. Res. (1994) [Pubmed]
  12. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams, L.D., Lemire, J.M., Schwartz, S.M. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  13. Osteonectin RNA and collagen alpha1(I) RNA in the developing rat maxilla. Liao, H., Brandsten, C., Lundmark, C., Christersson, C., Wurtz, T. Eur. J. Oral Sci. (1998) [Pubmed]
  14. Opposing influences of glucocorticoid and retinoic acid on transcriptional control in preosteoblasts. Ng, K.W., Manji, S.S., Young, M.F., Findlay, D.M. Mol. Endocrinol. (1989) [Pubmed]
  15. The partial degradation of osteonectin by a bone-derived metalloprotease enhances binding to type I collagen. Tyree, B. J. Bone Miner. Res. (1989) [Pubmed]
  16. Secreted protein acidic and rich in cysteine expression after subtotal nephrectomy and blockade of the renin-angiotensin system. Wu, L.L., Cox, A., Roe, C.J., Dziadek, M., Cooper, M.E., Gilbert, R.E. J. Am. Soc. Nephrol. (1997) [Pubmed]
  17. Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1. Witzgall, R., Volk, R., Yeung, R.S., Bonventre, J.V. Genomics (1994) [Pubmed]
  18. Coordinate gene expression during neonatal rat heart development. A possible role for the myocyte in extracellular matrix biogenesis and capillary angiogenesis. Engelmann, G.L. Cardiovasc. Res. (1993) [Pubmed]
  19. Type IV collagen and laminin regulate glomerular mesangial cell susceptibility to apoptosis via beta(1) integrin-mediated survival signals. Mooney, A., Jackson, K., Bacon, R., Streuli, C., Edwards, G., Bassuk, J., Savill, J. Am. J. Pathol. (1999) [Pubmed]
  20. Expression of bone matrix proteins mRNA during distraction osteogenesis. Sato, M., Yasui, N., Nakase, T., Kawahata, H., Sugimoto, M., Hirota, S., Kitamura, Y., Nomura, S., Ochi, T. J. Bone Miner. Res. (1998) [Pubmed]
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