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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Dentin


High impact information on Dentin

  • Dentinogenesis imperfecta 1 (DGI1, MIM 125490) is an autosomal dominant dental disease characterized by abnormal dentin production and mineralization [6].
  • The osteonectin-collagen complexes also nucleate mineral phase deposition from metastable balanced salt solutions, Antibodies to osteonectin cross-react with bone and, to a lesser extent, dentin, but not with other tissues [7].
  • Aspartic acid racemisation in dentine as a measure of ageing [8].
  • Finally, like high-dose MCSF, overexpression of c-Fos normalizes the number of beta(3)(-/-) osteoclasts in vitro, but not their ability to resorb dentin [9].
  • To determine whether alkaline phosphatase (ALP) can cause the mineralization of collagenous matrices in vivo, bovine intestinal ALP was covalently bound to slices of guanidine-extracted demineralized bovine dentin (DDS) [10].

Chemical compound and disease context of Dentin


Biological context of Dentin

  • However, osteonectin, a 32,000 Mr bone-specific protein found previously to promote collagen mineralization in vitro and present in abundance (approximately equal to 3% of total protein) in normal calf bone, was severely depleted (less than 2% of normal levels) in the osteogenesis imperfecta bone and dentin [16].
  • A set of genes for dentine and bone extracellular matrix proteins constitutes an additional cluster distal to the EMP gene cluster, with similar structural features to EMP genes [17].
  • Here we show that Dmp-1 null mice postnatally develop a profound tooth phenotype characterized by a partial failure of maturation of predentin into dentin, enlarged pulp chambers, increased width of predentin zone with reduced dentin wall, and hypomineralization [18].
  • During the process of analyzing the 3' end of an odontoblast-specific cDNA which codes for dentin sialoprotein (Ritchie, H. H., Hou, H., Veis, A., and Butler, W. T. (1994) J. Biol. Chem. 269, 3698-3702), we discovered a 801-base pair open reading frame [19].
  • Lama2 mutant mice have thin dentin and a widely opened dentinal tube, as compared with wild-type and heterozygote mice, which is similar to the phenotype of dentinogenesis imperfecta [20].

Anatomical context of Dentin

  • To confirm these in vivo findings, we cultured src-mutant bone marrow cells on dentine slices in the presence of 1,25 dihydroxyvitamin D3 [21].
  • The continuing expression of NGFR-IR by pulpal mesenchymal cells in adult rats was most intense near coronal odontoblasts making tubular dentin; and it was lost during aging, or subjacent to sites of dentin injury that caused a phenotypic change in the odontoblast layer [22].
  • Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development [18].
  • Polyclonal antibodies were raised in chicken against recombinant pig DSP, and used to identify native DSP in fractions of tooth dentin proteins extracted from developing pig molars [23].
  • Dentin extracellular matrix components such as type I and III collagens are increased and deposited abnormally in the dental pulp, similar to the hereditary human tooth disorders such as dentin dysplasia and dentinogenesis imperfecta [24].

Associations of Dentin with chemical compounds


Gene context of Dentin

  • Dentin matrix protein 1 (DMP1) is an acidic noncollagenous protein shown by gene ablations to be critical for the proper mineralization of bone and dentin [27].
  • Overall, our results identify a crucial role for Dspp in orchestrating the events essential during dentin mineralization, including potential regulation of proteoglycan levels [28].
  • Dentin matrix protein 1 (DMP1) is a bone- and teeth-specific protein initially identified from mineralized dentin [29].
  • Here we report the isolation and characterization of a third domain of DSPP, designated dentin glycoprotein (DGP) [26].
  • Interestingly, the levels of biglycan and decorin, small leucine-rich proteoglycans, were increased in the widened predentin zone and in void spaces among the calcospherites in the dentin of null teeth [28].

Analytical, diagnostic and therapeutic context of Dentin


  1. Insulin-like growth factor-I supports formation and activation of osteoclasts. Mochizuki, H., Hakeda, Y., Wakatsuki, N., Usui, N., Akashi, S., Sato, T., Tanaka, K., Kumegawa, M. Endocrinology (1992) [Pubmed]
  2. A bone sialoprotein-binding protein from Staphylococcus aureus: a member of the staphylococcal Sdr family. Tung, H., Guss, B., Hellman, U., Persson, L., Rubin, K., Rydén, C. Biochem. J. (2000) [Pubmed]
  3. Molecular structure of acid-etched dentin smear layers--in situ study. Sencer, P., Wang, Y., Walker, M.P., Swafford, J.R. J. Dent. Res. (2001) [Pubmed]
  4. Effects of thermocycling and occlusal force on adhesive composite crowns. Krejci, I., Mueller, E., Lutz, F. J. Dent. Res. (1994) [Pubmed]
  5. The occurrence of interglobular dentin in incisors of hypophosphatemic mice fed a high-calcium and high-phosphate diet. Abe, K., Masatomi, Y., Nakajima, Y., Shintani, S., Moriwaki, Y., Sobue, S., Ooshima, T. J. Dent. Res. (1992) [Pubmed]
  6. Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Xiao, S., Yu, C., Chou, X., Yuan, W., Wang, Y., Bu, L., Fu, G., Qian, M., Yang, J., Shi, Y., Hu, L., Han, B., Wang, Z., Huang, W., Liu, J., Chen, Z., Zhao, G., Kong, X. Nat. Genet. (2001) [Pubmed]
  7. Osteonectin, a bone-specific protein linking mineral to collagen. Termine, J.D., Kleinman, H.K., Whitson, S.W., Conn, K.M., McGarvey, M.L., Martin, G.R. Cell (1981) [Pubmed]
  8. Aspartic acid racemisation in dentine as a measure of ageing. Helfman, P.M., Bada, J.L. Nature (1976) [Pubmed]
  9. c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. Faccio, R., Takeshita, S., Zallone, A., Ross, F.P., Teitelbaum, S.L. J. Clin. Invest. (2003) [Pubmed]
  10. Alkaline phosphatase induces the mineralization of sheets of collagen implanted subcutaneously in the rat. Beertsen, W., van den Bos, T. J. Clin. Invest. (1992) [Pubmed]
  11. The effects of calcium hydroxide on dentin permeability. Pashley, D.H., Kalathoor, S., Burnham, D. J. Dent. Res. (1986) [Pubmed]
  12. The efficacy of potassium salts as agents for treating dentin hypersensitivity. Orchardson, R., Gillam, D.G. Journal of orofacial pain. (2000) [Pubmed]
  13. A useful method to evaluate bone resorption inhibitors, using osteoclast-like multinucleated cells. Sugawara, K., Hamada, M., Hosoi, S., Tamaoki, T. Anal. Biochem. (1998) [Pubmed]
  14. Dentine hypersensitivity: a clinical trial to compare 2 strontium densensitizing toothpastes with a conventional fluoride toothpaste. Pearce, N.X., Addy, M., Newcombe, R.G. J. Periodontol. (1994) [Pubmed]
  15. Generalized cervical root resorption associated with periodontal disease. Beertsen, W., Piscaer, M., Van Winkelhoff, A.J., Everts, V. Journal of clinical periodontology. (2001) [Pubmed]
  16. Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta. Termine, J.D., Robey, P.G., Fisher, L.W., Shimokawa, H., Drum, M.A., Conn, K.M., Hawkins, G.R., Cruz, J.B., Thompson, K.G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  17. Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene cluster. Kawasaki, K., Weiss, K.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  18. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., Feng, J.Q. J. Biol. Chem. (2004) [Pubmed]
  19. Sequence determination of an extremely acidic rat dentin phosphoprotein. Ritchie, H.H., Wang, L.H. J. Biol. Chem. (1996) [Pubmed]
  20. Laminin alpha2 is essential for odontoblast differentiation regulating dentin sialoprotein expression. Yuasa, K., Fukumoto, S., Kamasaki, Y., Yamada, A., Fukumoto, E., Kanaoka, K., Saito, K., Harada, H., Arikawa-Hirasawa, E., Miyagoe-Suzuki, Y., Takeda, S., Okamoto, K., Kato, Y., Fujiwara, T. J. Biol. Chem. (2004) [Pubmed]
  21. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. Boyce, B.F., Yoneda, T., Lowe, C., Soriano, P., Mundy, G.R. J. Clin. Invest. (1992) [Pubmed]
  22. Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity. Byers, M.R., Schatteman, G.C., Bothwell, M. Development (1990) [Pubmed]
  23. Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate. Yamakoshi, Y., Hu, J.C., Fukae, M., Iwata, T., Kim, J.W., Zhang, H., Simmer, J.P. J. Biol. Chem. (2005) [Pubmed]
  24. Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth. Thyagarajan, T., Sreenath, T., Cho, A., Wright, J.T., Kulkarni, A.B. J. Biol. Chem. (2001) [Pubmed]
  25. Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Shakespeare, W., Yang, M., Bohacek, R., Cerasoli, F., Stebbins, K., Sundaramoorthi, R., Azimioara, M., Vu, C., Pradeepan, S., Metcalf, C., Haraldson, C., Merry, T., Dalgarno, D., Narula, S., Hatada, M., Lu, X., van Schravendijk, M.R., Adams, S., Violette, S., Smith, J., Guan, W., Bartlett, C., Herson, J., Iuliucci, J., Weigele, M., Sawyer, T. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  26. Dentin glycoprotein: the protein in the middle of the dentin sialophosphoprotein chimera. Yamakoshi, Y., Hu, J.C., Fukae, M., Zhang, H., Simmer, J.P. J. Biol. Chem. (2005) [Pubmed]
  27. A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment. Qin, C., Huang, B., Wygant, J.N., McIntyre, B.W., McDonald, C.H., Cook, R.G., Butler, W.T. J. Biol. Chem. (2006) [Pubmed]
  28. Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. Sreenath, T., Thyagarajan, T., Hall, B., Longenecker, G., D'Souza, R., Hong, S., Wright, J.T., MacDougall, M., Sauk, J., Kulkarni, A.B. J. Biol. Chem. (2003) [Pubmed]
  29. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. Narayanan, K., Ramachandran, A., Hao, J., He, G., Park, K.W., Cho, M., George, A. J. Biol. Chem. (2003) [Pubmed]
  30. TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption. Kwon, B.S., Wang, S., Udagawa, N., Haridas, V., Lee, Z.H., Kim, K.K., Oh, K.O., Greene, J., Li, Y., Su, J., Gentz, R., Aggarwal, B.B., Ni, J. FASEB J. (1998) [Pubmed]
  31. Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. Nakano, K., Okada, Y., Saito, K., Tanaka, Y. Arthritis Rheum. (2004) [Pubmed]
  32. Cloning and sequence determination of rat dentin sialoprotein, a novel dentin protein. Ritchie, H.H., Hou, H., Veis, A., Butler, W.T. J. Biol. Chem. (1994) [Pubmed]
  33. Induction of dental pulp stem cell differentiation into odontoblasts by electroporation-mediated gene delivery of growth/differentiation factor 11 (Gdf11). Nakashima, M., Mizunuma, K., Murakami, T., Akamine, A. Gene Ther. (2002) [Pubmed]
  34. A histological investigation of isografts of mature mouse molars to an intrabony and an extrabony site. Barrett, A.P., Reade, P.C. Transplantation (1981) [Pubmed]
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