Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ptgs2a - prostaglandin-endoperoxide synthase 2a

Danio rerio

Synonyms: SO:0000704, fj02a10, ptgs2, unp1239, wu:fj02a10, ...

Grosser, T. et al.

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High impact information on ptgs2a

Both zCOXs were widely expressed during development, and knockdown of zCOX-1 causes growth arrest during early embryogenesis. zCOX-1 is widely evident in the embryonic vasculature, whereas zCOX-2 exhibits a more restricted pattern of expression [1].
Full-length cDNAs of zCOX-1 and zCOX-2 were cloned and assigned to conserved regions of chromosomes 5 and 2, respectively [1].

Biological context of ptgs2a

Zebrafish thrombocyte aggregation ex vivo and hemostasis in vivo are sensitive to inhibition of zCOX-1, but not zCOX-2 [1].

References

Developmental expression of functional cyclooxygenases in zebrafish. Grosser, T., Yusuff, S., Cheskis, E., Pack, M.A., FitzGerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]

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