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Gene Review

ptgs1  -  prostaglandin-endoperoxide synthase 1

Danio rerio

Synonyms: SO:0000704, cox1, zCOX-1
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High impact information on ptgs1

  • Both zCOXs were widely expressed during development, and knockdown of zCOX-1 causes growth arrest during early embryogenesis. zCOX-1 is widely evident in the embryonic vasculature, whereas zCOX-2 exhibits a more restricted pattern of expression [1].
  • Full-length cDNAs of zCOX-1 and zCOX-2 were cloned and assigned to conserved regions of chromosomes 5 and 2, respectively [1].
  • Prostaglandin (PG) E(2) is the predominant zCOX product detected by mass spectrometry [1].
  • METHODS AND RESULTS: We cloned zebrafish cytosolic (c) and m-PGES orthologs and mapped them to syntenic regions of chromosomes 23 and 5. cPGES was widely expressed during development and was coordinately regulated with zCOX-1 in the inner ear, the pronephros, and intestine [2].

Biological context of ptgs1


  1. Developmental expression of functional cyclooxygenases in zebrafish. Grosser, T., Yusuff, S., Cheskis, E., Pack, M.A., FitzGerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Prostaglandin E synthases in zebrafish. Pini, B., Grosser, T., Lawson, J.A., Price, T.S., Pack, M.A., FitzGerald, G.A. Arterioscler. Thromb. Vasc. Biol. (2005) [Pubmed]
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