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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hemostasis


Psychiatry related information on Hemostasis


High impact information on Hemostasis


Chemical compound and disease context of Hemostasis


Biological context of Hemostasis

  • Therefore, Plg plays a pivotal role in fibrinolysis and hemostasis but is not essential for urokinase proenzyme activation, development, or growth to sexual maturity [17].
  • Thromboxane A2 (TXA2) receptor is a member of the family of G protein-coupled receptors and performs an essential role in hemostasis by interacting with TXA2 to induce platelet aggregation [18].
  • Our results indicate that hepsin is not essential for embryonic development and normal hemostasis [19].
  • Rescued mice (mTF-/-, hTF+), which expressed low levels (approximately 1%) of TF activity, developed normally with no signs of a bleeding diathesis, suggesting that low TF expression can maintain hemostasis compatible with normal survival [20].
  • Overexpression and silencing of KLF2 in the context of flow, combined with findings from genome-wide analyses of gene expression, demonstrate that the induction of KLF2 results in the orchestrated regulation of endothelial transcriptional programs controlling inflammation, thrombosis/hemostasis, vascular tone, and blood vessel development [21].

Anatomical context of Hemostasis


Associations of Hemostasis with chemical compounds

  • Platelets stimulated with thrombin or calcium ionophore (A23187) secrete a protein functionally and immunologically identical to the inhibitor, implying a role for this inhibitor in hemostasis [27].
  • To explore the role of the key coagulation factor, fibrinogen, in development, hemostasis, wound repair, and disease pathogenesis, we disrupted the fibrinogen A alpha chain gene in mice [28].
  • In addition, our data support the concept that the interaction of fibrinogen and/or von Willebrand factor with the platelet glycoprotein IIb-IIIa complex is essential for effective hemostasis [29].
  • These studies establish the importance of the membrane-distal portion of the integrin beta3 cytoplasmic domain in bidirectional transmembrane signaling in human platelets, and the role of integrin signaling in maintaining normal hemostasis in vivo [30].
  • An important determinant of platelet-vessel wall interactions is the local balance of production of endothelial prostacyclin (PGI2) and platelet thromboxane (TX) A2, labile eicosanoids with opposing effects on hemostasis [31].

Gene context of Hemostasis

  • Plasminogen (Plg)-deficient mice were generated to define the physiological roles of this key fibrinolytic protein and its proteolytic derivatives, plasmin and angiostatin, in development, hemostasis, and reproduction [17].
  • These studies support the hypothesis that TSP, acting as a multifunctional regulator in focal areas of active hemostasis, could serve as a prothrombotic influence, leading to increased deposition of fibrin [32].
  • These results reveal a novel receptor-dependent effect of leptin on platelet function and hemostasis and provide new insights into the molecular basis of cardiovascular complications in obese individuals [33].
  • Rap1b is required for normal platelet function and hemostasis in mice [34].
  • Tissue factor (TF) plays an important role in hemostasis, inflammation, angiogenesis, and the pathophysiology of atherosclerosis and cancer [35].

Analytical, diagnostic and therapeutic context of Hemostasis


  1. Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Walther, D.J., Peter, J.U., Winter, S., Höltje, M., Paulmann, N., Grohmann, M., Vowinckel, J., Alamo-Bethencourt, V., Wilhelm, C.S., Ahnert-Hilger, G., Bader, M. Cell (2003) [Pubmed]
  2. G13 is an essential mediator of platelet activation in hemostasis and thrombosis. Moers, A., Nieswandt, B., Massberg, S., Wettschureck, N., Grüner, S., Konrad, I., Schulte, V., Aktas, B., Gratacap, M.P., Simon, M.I., Gawaz, M., Offermanns, S. Nat. Med. (2003) [Pubmed]
  3. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Hrachovinová, I., Cambien, B., Hafezi-Moghadam, A., Kappelmayer, J., Camphausen, R.T., Widom, A., Xia, L., Kazazian, H.H., Schaub, R.G., McEver, R.P., Wagner, D.D. Nat. Med. (2003) [Pubmed]
  4. Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Sakai, T., Johnson, K.J., Murozono, M., Sakai, K., Magnuson, M.A., Wieloch, T., Cronberg, T., Isshiki, A., Erickson, H.P., Fässler, R. Nat. Med. (2001) [Pubmed]
  5. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. Carmeliet, P., Stassen, J.M., Schoonjans, L., Ream, B., van den Oord, J.J., De Mol, M., Mulligan, R.C., Collen, D. J. Clin. Invest. (1993) [Pubmed]
  6. The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms. Colombatti, A., Bonaldo, P. Blood (1991) [Pubmed]
  7. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. Lau, J.Y., Sung, J.J., Lee, K.K., Yung, M.Y., Wong, S.K., Wu, J.C., Chan, F.K., Ng, E.K., You, J.H., Lee, C.W., Chan, A.C., Chung, S.C. N. Engl. J. Med. (2000) [Pubmed]
  8. Treatment with desmopressin acetate to reduce blood loss after cardiac surgery. A double-blind randomized trial. Salzman, E.W., Weinstein, M.J., Weintraub, R.M., Ware, J.A., Thurer, R.L., Robertson, L., Donovan, A., Gaffney, T., Bertele, V., Troll, J. N. Engl. J. Med. (1986) [Pubmed]
  9. Effects of acetylsalicylic-acid ingestion on maternal and neonatal hemostasis. Stuart, M.J., Gross, S.J., Elrad, H., Graeber, J.E. N. Engl. J. Med. (1982) [Pubmed]
  10. Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. Angelillo-Scherrer, A., de Frutos, P., Aparicio, C., Melis, E., Savi, P., Lupu, F., Arnout, J., Dewerchin, M., Hoylaerts, M., Herbert, J., Collen, D., Dahlbäck, B., Carmeliet, P. Nat. Med. (2001) [Pubmed]
  11. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Enjyoji, K., Sévigny, J., Lin, Y., Frenette, P.S., Christie, P.D., Esch, J.S., Imai, M., Edelberg, J.M., Rayburn, H., Lech, M., Beeler, D.L., Csizmadia, E., Wagner, D.D., Robson, S.C., Rosenberg, R.D. Nat. Med. (1999) [Pubmed]
  12. Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb. O'Toole, T.E., Mandelman, D., Forsyth, J., Shattil, S.J., Plow, E.F., Ginsberg, M.H. Science (1991) [Pubmed]
  13. Impairment of hemostasis in patients with severe hemophilia. Failure of diphenhydramine, chlorpromazine, and guaifenesin. Buchanan, G.R., Handin, R.I. JAMA (1978) [Pubmed]
  14. Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII. Margaritis, P., Arruda, V.R., Aljamali, M., Camire, R.M., Schlachterman, A., High, K.A. J. Clin. Invest. (2004) [Pubmed]
  15. Propranolol in the prevention of recurrent variceal hemorrhage in cirrhotic patients. A controlled trial. Garden, O.J., Mills, P.R., Birnie, G.G., Murray, G.D., Carter, D.C. Gastroenterology (1990) [Pubmed]
  16. von Willebrand factor conformation and adhesive function is modulated by an internalized water molecule. Celikel, R., Ruggeri, Z.M., Varughese, K.I. Nat. Struct. Biol. (2000) [Pubmed]
  17. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Bugge, T.H., Flick, M.J., Daugherty, C.C., Degen, J.L. Genes Dev. (1995) [Pubmed]
  18. Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder. Hirata, T., Kakizuka, A., Ushikubi, F., Fuse, I., Okuma, M., Narumiya, S. J. Clin. Invest. (1994) [Pubmed]
  19. Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. Wu, Q., Yu, D., Post, J., Halks-Miller, M., Sadler, J.E., Morser, J. J. Clin. Invest. (1998) [Pubmed]
  20. Low levels of tissue factor are compatible with development and hemostasis in mice. Parry, G.C., Erlich, J.H., Carmeliet, P., Luther, T., Mackman, N. J. Clin. Invest. (1998) [Pubmed]
  21. Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2. Parmar, K.M., Larman, H.B., Dai, G., Zhang, Y., Wang, E.T., Moorthy, S.N., Kratz, J.R., Lin, Z., Jain, M.K., Gimbrone, M.A., García-Cardeña, G. J. Clin. Invest. (2006) [Pubmed]
  22. Zinc finger protein, Hzf, is required for megakaryocyte development and hemostasis. Kimura, Y., Hart, A., Hirashima, M., Wang, C., Holmyard, D., Pittman, J., Pang, X.L., Jackson, C.W., Bernstein, A. J. Exp. Med. (2002) [Pubmed]
  23. Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties. Bar-Shavit, R., Eldor, A., Vlodavsky, I. J. Clin. Invest. (1989) [Pubmed]
  24. Developmental expression of functional cyclooxygenases in zebrafish. Grosser, T., Yusuff, S., Cheskis, E., Pack, M.A., FitzGerald, G.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., Wilcox, D.A. Blood (2005) [Pubmed]
  26. Platelet-dependent primary hemostasis promotes selectin- and integrin-mediated neutrophil adhesion to damaged endothelium under flow conditions. Kuijper, P.H., Gallardo Torres, H.I., van der Linden, J.A., Lammers, J.W., Sixma, J.J., Koenderman, L., Zwaginga, J.J. Blood (1996) [Pubmed]
  27. Platelet coagulation factor XIa-inhibitor, a form of Alzheimer amyloid precursor protein. Smith, R.P., Higuchi, D.A., Broze, G.J. Science (1990) [Pubmed]
  28. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Suh, T.T., Holmbäck, K., Jensen, N.J., Daugherty, C.C., Small, K., Simon, D.I., Potter, S., Degen, J.L. Genes Dev. (1995) [Pubmed]
  29. A myeloma paraprotein with specificity for platelet glycoprotein IIIa in a patient with a fatal bleeding disorder. DiMinno, G., Coraggio, F., Cerbone, A.M., Capitanio, A.M., Manzo, C., Spina, M., Scarpato, P., Dattoli, G.M., Mattioli, P.L., Mancini, M. J. Clin. Invest. (1986) [Pubmed]
  30. Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex. Wang, R., Shattil, S.J., Ambruso, D.R., Newman, P.J. J. Clin. Invest. (1997) [Pubmed]
  31. Unidirectional transfer of prostaglandin endoperoxides between platelets and endothelial cells. Schafer, A.I., Crawford, D.D., Gimbrone, M.A. J. Clin. Invest. (1984) [Pubmed]
  32. Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator. Silverstein, R.L., Leung, L.L., Harpel, P.C., Nachman, R.L. J. Clin. Invest. (1984) [Pubmed]
  33. Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. Konstantinides, S., Schäfer, K., Koschnick, S., Loskutoff, D.J. J. Clin. Invest. (2001) [Pubmed]
  34. Rap1b is required for normal platelet function and hemostasis in mice. Chrzanowska-Wodnicka, M., Smyth, S.S., Schoenwaelder, S.M., Fischer, T.H., White, G.C. J. Clin. Invest. (2005) [Pubmed]
  35. Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor. Hackeng, T.M., Seré, K.M., Tans, G., Rosing, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  36. Low-molecular-weight heparin as bridging anticoagulation during interruption of warfarin: assessment of a standardized periprocedural anticoagulation regimen. Douketis, J.D., Johnson, J.A., Turpie, A.G. Arch. Intern. Med. (2004) [Pubmed]
  37. Collagen application versus manual compression: a prospective randomized trial for arterial puncture site closure after coronary angioplasty. Camenzind, E., Grossholz, M., Urban, P., Dorsaz, P.A., Didier, D., Meier, B. J. Am. Coll. Cardiol. (1994) [Pubmed]
  38. Adverse outcome of human islet-allogeneic blood interaction. Titus, T.T., Horton, P.J., Badet, L., Handa, A., Chang, L., Agarwal, A., McShane, P., Giangrande, P., Gray, D.W. Transplantation (2003) [Pubmed]
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