The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Platelets

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Blood Platelets

  • Furthermore, a significantly lower than normal serotonin accumulation rate was also detected in dense granules isolated from blood platelets of Down's syndrome individuals [1].
  • Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA [2].
  • We have examined human and rabbit blood platelets for expression of pp60c-src, the normal cellular homolog of the transforming protein of Rous sarcoma virus. pp60c-src kinase activity was determined by an immune-complex kinase assay that uses enolase as the substrate, and pp60c-src protein levels were determined by an immunoblot assay [3].
  • In contrast to the Fab fragments from the autoimmune thrombocytopenia patient who developed SLE, none of the IVIG-selected Fabs from the SLE patient without thrombocytopenia bound to thrombocytes [4].
  • In pathophysiologic terms, the reaction of IgG antiglobulin complexes with thrombocytes in vivo may be an important step in the chain of events leading to generalized vascular damage and deposition of immune complexes in vessel walls which is thought to be responsible for the development of generalized vasculitis in RA [5].

Psychiatry related information on Blood Platelets


High impact information on Blood Platelets


Chemical compound and disease context of Blood Platelets


Biological context of Blood Platelets


Anatomical context of Blood Platelets


Associations of Blood Platelets with chemical compounds


Gene context of Blood Platelets


Analytical, diagnostic and therapeutic context of Blood Platelets


  1. Diminished serotonin uptake in platelets of transgenic mice with increased Cu/Zn-superoxide dismutase activity. Schickler, M., Knobler, H., Avraham, K.B., Elroy-Stein, O., Groner, Y. EMBO J. (1989) [Pubmed]
  2. Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA. Cannizzo, S.J., Frey, B.M., Raffi, S., Moore, M.A., Eaton, D., Suzuki, M., Singh, R., Mack, C.A., Crystal, R.G. Nat. Biotechnol. (1997) [Pubmed]
  3. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Golden, A., Nemeth, S.P., Brugge, J.S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Restricted VH3 gene usage in phage-displayed Fab that are selected by intravenous immunoglobulin. Osei, A., Uttenreuther-Fischer, M.M., Lerch, H., Gaedicke, G., Fischer, P. Arthritis Rheum. (2000) [Pubmed]
  5. Platelet aggregation and aggregation inhibition by different antiglobulins and antiglobulin complexes from sera of patients with rheumatoid arthritis. Fink, P.C., Piening, U., Fricke, P.M., Deicher, H. Arthritis Rheum. (1979) [Pubmed]
  6. Acetaminophen sulfation in patients with Parkinson's disease or Huntington's disease is not impaired. Roos, R.A., Steenvoorden, J.M., Mulder, G.J., Van Kempen, G.M. Neurology (1993) [Pubmed]
  7. Serotonin uptake and imipramine binding in the blood platelets of obsessive-compulsive disorder patients. Bastani, B., Arora, R.C., Meltzer, H.Y. Biol. Psychiatry (1991) [Pubmed]
  8. Serotonin uptake in the blood platelets of Alzheimer's disease patients. Arora, R.C., Emery, O.B., Meltzer, H.Y. Neurology (1991) [Pubmed]
  9. Altered 5-HT-induced calcium response in the presence of staurosporine in blood platelets from bipolar disorder patients. Suzuki, K., Kusumi, I., Akimoto, T., Sasaki, Y., Koyama, T. Neuropsychopharmacology (2003) [Pubmed]
  10. Serotonin 5-HT2 receptor binding on blood platelets as a state dependent marker in major affective disorder. Biegon, A., Essar, N., Israeli, M., Elizur, A., Bruch, S., Bar-Nathan, A.A. Psychopharmacology (Berl.) (1990) [Pubmed]
  11. A study of protein phosphorylation in shape change and Ca++-dependent serotonin release by blood platelets. Bennett, W.F., Belville, J.S., Lynch, G. Cell (1979) [Pubmed]
  12. Diacylglycerol in large alpha-actinin/actin complexes and in the cytoskeleton of activated platelets. Burn, P., Rotman, A., Meyer, R.K., Burger, M.M. Nature (1985) [Pubmed]
  13. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nieuwenhuis, H.K., Akkerman, J.W., Houdijk, W.P., Sixma, J.J. Nature (1985) [Pubmed]
  14. Blood platelets do not provide endoperoxides for vascular prostacyclin production. Hornstra, G., Haddeman, E., Don, J.A. Nature (1979) [Pubmed]
  15. Selective inhibition of thromboxane A2 biosynthesis in blood platelets. Gryglewski, R.J., Zmuda, A., Korbut, R., Krecioch, E., Bieron, K. Nature (1977) [Pubmed]
  16. Endotoxin-induced platelet aggregation and secretion. I. Morphological changes and pharmacological effects. MacIntyre, D.E., Allen, A.P., Thorne, K.J., Glauert, A.M., Gordon, J.L. J. Cell. Sci. (1977) [Pubmed]
  17. Stearic acid, clotting, and thrombosis. Hoak, J.C. Am. J. Clin. Nutr. (1994) [Pubmed]
  18. The contribution of vascular obstruction to the functional defect that follows renal ischemia. Mason, J., Welsch, J., Torhorst, J. Kidney Int. (1987) [Pubmed]
  19. Does a predisposition to the metabolic syndrome sensitize women to develop pre-eclampsia? Barden, A.E., Beilin, L.J., Ritchie, J., Walters, B.N., Michael, C. J. Hypertens. (1999) [Pubmed]
  20. Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal function. Gleissner, C.A., Murat, A., Schäfer, S., Klingenberg, R., Koch, A., Remppis, A., Zimmermann, R., Katus, H.A., Dengler, T.J. Transplantation (2004) [Pubmed]
  21. Lowering pH in blood platelets dissociates myosin phosphorylation from shape change and myosin association with the cytoskeleton. Nachmias, V.T., Yoshida, K., Glennon, M.C. J. Cell Biol. (1987) [Pubmed]
  22. Prostaglandin-stimulated GTP hydrolysis associated with activation of adenylate cyclase in human platelet membranes. Lester, H.A., Steer, M.L., Levitzki, A. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  23. Severe von Willebrand disease due to a defect at the level of von Willebrand factor mRNA expression: detection by exonic PCR-restriction fragment length polymorphism analysis. Nichols, W.C., Lyons, S.E., Harrison, J.S., Cody, R.L., Ginsburg, D. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  24. Allele-dependent transcriptional regulation of the human integrin alpha2 gene. Jacquelin, B., Tarantino, M.D., Kritzik, M., Rozenshteyn, D., Koziol, J.A., Nurden, A.T., Kunicki, T.J. Blood (2001) [Pubmed]
  25. Expression of the thrombopoietin gene in human fetal and neonatal tissues. Wolber, E.M., Dame, C., Fahnenstich, H., Hofmann, D., Bartmann, P., Jelkmann, W., Fandrey, J. Blood (1999) [Pubmed]
  26. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. Tanaka, M., Kishimura, M., Ozaki, S., Osakada, F., Hashimoto, H., Okubo, M., Murakami, M., Nakao, K. J. Clin. Invest. (2000) [Pubmed]
  27. Interferon enhances prostacyclin production by cultured vascular endothelial cells. Eldor, A., Fridman, R., Vlodavsky, I., Hy-Am, E., Fuks, Z., Panet, A. J. Clin. Invest. (1984) [Pubmed]
  28. Possible involvement of blood platelet/megakaryocyte system in alpha-1-antitrypsin deficiency. Miale, T.D., Lawson, D.L., Demian, S., Teague, P.O., Wolfson, S.L. Lancet (1977) [Pubmed]
  29. The human platelet. A diagnostic and research tool for the study of biogenic amines in psychiatric and neurologic disorders. Stahl, S.M. Arch. Gen. Psychiatry (1977) [Pubmed]
  30. Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid. Maclouf, J., de Laclos, B.F., Borgeat, P. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  31. Cytochalasin B, the blood platelet release reaction and cyclic GMP. Haslam, R.J., Davidson, M.M., McClenaghan, M.D. Nature (1975) [Pubmed]
  32. Prostaglandin E1 inhibitis platelet aggregation by a pathway independent of adenosine 3',5'-monophosphate. Sinha, A.K., Colman, R.W. Science (1978) [Pubmed]
  33. 2,3-diphosphoglycerate: a physiological inhibitor of platelet aggregation. Iatridis, S.G., Iatridis, P.G., Markidou, S.G., Ragatz, B.H. Science (1975) [Pubmed]
  34. 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. Macfarlane, D.E., Srivastava, P.C., Mills, D.C. J. Clin. Invest. (1983) [Pubmed]
  35. Transfer of adenine nucleotides between the releasable and nonreleasable compartments of rabbit blood platelets. Reimers, H.J., Mustard, J.F., Packham, M.A. J. Cell Biol. (1975) [Pubmed]
  36. Complex formation of platelet thrombospondin with histidine-rich glycoprotein. Leung, L.L., Nachman, R.L., Harpel, P.C. J. Clin. Invest. (1984) [Pubmed]
  37. Platelet release of trimolecular complex components MT1-MMP/TIMP2/MMP2: involvement in MMP2 activation and platelet aggregation. Kazes, I., Elalamy, I., Sraer, J.D., Hatmi, M., Nguyen, G. Blood (2000) [Pubmed]
  38. CD36 associates with CD9 and integrins on human blood platelets. Miao, W.M., Vasile, E., Lane, W.S., Lawler, J. Blood (2001) [Pubmed]
  39. Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes. Li, J., Avraham, H., Rogers, R.A., Raja, S., Avraham, S. Blood (1996) [Pubmed]
  40. Phenotypic and functional evidence for the expression of CXCR4 receptor during megakaryocytopoiesis. Rivière, C., Subra, F., Cohen-Solal, K., Cordette-Lagarde, V., Letestu, R., Auclair, C., Vainchenker, W., Louache, F. Blood (1999) [Pubmed]
  41. Immunocytochemical localization of fibrinogen, platelet factor 4, and beta thromboglobulin in thin frozen sections of human blood platelets. Sander, H.J., Slot, J.W., Bouma, B.N., Bolhuis, P.A., Pepper, D.S., Sixma, J.J. J. Clin. Invest. (1983) [Pubmed]
  42. Effect of atherosclerosis on endothelium-dependent inhibition of platelet activation in humans. Diodati, J.G., Dakak, N., Gilligan, D.M., Quyyumi, A.A. Circulation (1998) [Pubmed]
  43. Synthesis of analogs of human platelet membrane glycoprotein IIb-IIIa complex by chicken peripheral blood thrombocytes. Kunicki, T.J., Newman, P.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  44. Production of functional platelets by differentiated embryonic stem (ES) cells in vitro. Fujimoto, T.T., Kohata, S., Suzuki, H., Miyazaki, H., Fujimura, K. Blood (2003) [Pubmed]
  45. Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets. Ushikubi, F., Nakajima, M., Hirata, M., Okuma, M., Fujiwara, M., Narumiya, S. J. Biol. Chem. (1989) [Pubmed]
WikiGenes - Universities