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Gene Review:

Pde4b - phosphodiesterase 4B, cAMP specific

Rattus norvegicus

Synonyms: DPDE4, PDE4/IVb, Pde4B1, Pde4B2, Pde4B3, ...

Polesskaya, O.O. et al., Tissir, F. et al.

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High impact information on Pde4b

CONCLUSIONS: Chronic nicotine treatments produce a dose-dependent down-regulation of Pde4b, which may have an antidepressant effect [1].
RESULTS: We found a consistent decrease in the mRNA levels encoded by the Pde4b gene in nucleus accumbens, prefrontal cortex, and hippocampus of adolescent female rats treated with .24 mg/day nicotine, and in prefrontal cortex of adolescent female rats treated with .12 mg/day nicotine [1].
Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1) [2].

References

Chronic Nicotine Doses Down-Regulate PDE4 Isoforms that Are Targets of Antidepressants in Adolescent Female Rats. Polesskaya, O.O., Smith, R.F., Fryxell, K.J. Biol. Psychiatry (2007) [Pubmed]
Regional localization of the rat genes encoding the cAMP-specific phosphodiesterases 3 (Pde4d) and 4 (Pde4b) and the tyrosinase-related protein 1 (Tyrp1). Tissir, F., Champagne, B., Klinga-Levan, K., Levan, G., Szpirer, J., Szpirer, C. Mamm. Genome (1996) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PDE4B	Bos taurus
PDE4B	Canis lupus familiaris
pde4ba	Danio rerio
PDE4B	Gallus gallus
PDE4B	Homo sapiens
PDE4B	Macaca mulatta
Pde4b	Mus musculus
PDE4B	Pan troglodytes
pde4c	Xenopus (Silurana) tropicalis

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