Gene Review:
PDE4B - phosphodiesterase 4B, cAMP-specific
Homo sapiens
Synonyms:
DPDE4, PDE32, PDEIVB, cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Wang,
Wu,
Ohleth,
Egan,
Billah,
Jacob,
Leport,
Szilagyi,
Allen,
Bertrand,
Lagente,
Busch,
Liu,
Graveline,
Bloch,
Narita,
Murata,
Shimizu,
Nakagawa,
Sugiyama,
Inui,
Hiramoto,
Tagawa,
Leroy,
Méhats,
Duc-Goiran,
Tanguy,
Robert,
Dallot,
Mignot,
Grangé,
Ferré,
Ahlström,
Pekkinen,
Huttunen,
Lamberg-Allardt,
- A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells. Narita, M., Murata, T., Shimizu, K., Nakagawa, T., Sugiyama, T., Inui, M., Hiramoto, K., Tagawa, T. Oncol. Rep. (2007)
- The phosphodiesterase PDE4B limits cAMP-associated PI3K/AKT-dependent apoptosis in diffuse large B-cell lymphoma. Smith, P.G., Wang, F., Wilkinson, K.N., Savage, K.J., Klein, U., Neuberg, D.S., Bollag, G., Shipp, M.A., Aguiar, R.C. Blood (2005)
- Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells. Busch, C.J., Liu, H., Graveline, A.R., Bloch, K.D. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells. Amegadzie, B.Y., Hanning, C.R., McLaughlin, M.M., Burman, M., Cieslinski, L.B., Livi, G.P., Torphy, T.J. Cell Biol. Int. (1995)
- Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Jin, S.L., Conti, M. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Saldou, N., Obernolte, R., Huber, A., Baecker, P.A., Wilhelm, R., Alvarez, R., Li, B., Xia, L., Callan, O., Su, C., Jarnagin, K., Shelton, E.R. Cell. Signal. (1998)
- Prolonged beta adrenoceptor stimulation up-regulates cAMP phosphodiesterase activity in human monocytes by increasing mRNA and protein for phosphodiesterases 4A and 4B. Manning, C.D., McLaughlin, M.M., Livi, G.P., Cieslinski, L.B., Torphy, T.J., Barnette, M.S. J. Pharmacol. Exp. Ther. (1996)
- Suppression of human inflammatory cell function by subtype-selective PDE4 inhibitors correlates with inhibition of PDE4A and PDE4B. Manning, C.D., Burman, M., Christensen, S.B., Cieslinski, L.B., Essayan, D.M., Grous, M., Torphy, T.J., Barnette, M.S. Br. J. Pharmacol. (1999)
- Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation. Baroja, M.L., Cieslinski, L.B., Torphy, T.J., Wange, R.L., Madrenas, J. J. Immunol. (1999)
- Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils. Wang, P., Wu, P., Ohleth, K.M., Egan, R.W., Billah, M.M. Mol. Pharmacol. (1999)
- Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. Landells, L.J., Szilagy, C.M., Jones, N.A., Banner, K.H., Allen, J.M., Doherty, A., O'Connor, B.J., Spina, D., Page, C.P. Br. J. Pharmacol. (2001)
- DMSO-treated HL60 cells: a model of neutrophil-like cells mainly expressing PDE4B subtype. Jacob, C., Leport, M., Szilagyi, C., Allen, J.M., Bertrand, C., Lagente, V. Int. Immunopharmacol. (2002)
- Phosphodiesterase 4B gene transcription is activated by lipopolysaccharide and inhibited by interleukin-10 in human monocytes. Ma, D., Wu, P., Egan, R.W., Billah, M.M., Wang, P. Mol. Pharmacol. (1999)
- Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Moon, E., Lee, R., Near, R., Weintraub, L., Wolda, S., Lerner, A. Clin. Cancer Res. (2002)
- Cyclic AMP phosphodiesterases in the zebra finch: distribution, cloning and characterization of a PDE4B homolog. Thompson, B.E., Freking, F., Pho, V., Schlinger, B.A., Cherry, J.A. Brain Res. Mol. Brain Res. (2000)
- Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. Ahlström, M., Pekkinen, M., Huttunen, M., Lamberg-Allardt, C. Biochem. Pharmacol. (2005)
- Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium. Leroy, M.J., Méhats, C., Duc-Goiran, P., Tanguy, G., Robert, B., Dallot, E., Mignot, T.M., Grangé, G., Ferré, F. Cell. Signal. (1999)
- Identification of interaction sites of cyclic nucleotide phosphodiesterase type 3A with milrinone and cilostazol using molecular modeling and site-directed mutagenesis. Zhang, W., Ke, H., Colman, R.W. Mol. Pharmacol. (2002)
- The role of tryptophan 1072 in human PDE3B inhibitor binding. Chung, C., Varnerin, J.P., Morin, N.R., MacNeil, D.J., Singh, S.B., Patel, S., Scapin, G., Van der Ploeg, L.H., Tota, M.R. Biochem. Biophys. Res. Commun. (2003)
- Adaptation of cAMP signaling system in SH-SY5Y neuroblastoma cells following expression of a constitutively active stimulatory G protein alpha, Q227L Gsalpha. Jang, I.S., Juhnn, Y.S. Exp. Mol. Med. (2001)
- Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. Huston, E., Lumb, S., Russell, A., Catterall, C., Ross, A.H., Steele, M.R., Bolger, G.B., Perry, M.J., Owens, R.J., Houslay, M.D. Biochem. J. (1997)
- Identification of overlapping but distinct cAMP and cGMP interaction sites with cyclic nucleotide phosphodiesterase 3A by site-directed mutagenesis and molecular modeling based on crystalline PDE4B. Zhang, W., Ke, H., Tretiakova, A.P., Jameson, B., Colman, R.W. Protein Sci. (2001)