The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

FRA16D  -  fragile site, aphidicolin type, common,...

Homo sapiens

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FRA16D


High impact information on FRA16D


Biological context of FRA16D

  • APRT was found to be distal to HP and FRA16D and was localized at 16q24, making the gene order cen-FRA16B-HP-FRA16D-APRT-qter [7].
  • WWOX is a putative tumor suppressor gene that spans approximately a 1 Mb genomic region and is the site for the second most common chromosomal fragile site, FRA16D at 16q23 [8].
  • This led us to the identification and cloning of WWOX, a candidate tumor suppressor gene (TSG) that spans a fragile region of DNA located at 16q23.3-24.1 (FRA16D: the second most active common chromosomal fragile site in the human genome) [9].


  1. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. Fabbri, M., Iliopoulos, D., Trapasso, F., Aqeilan, R.I., Cimmino, A., Zanesi, N., Yendamuri, S., Han, S.Y., Amadori, D., Huebner, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. A role for the WWOX gene in prostate cancer. Qin, H.R., Iliopoulos, D., Semba, S., Fabbri, M., Druck, T., Volinia, S., Croce, C.M., Morrison, C.D., Klein, R.D., Huebner, K. Cancer Res. (2006) [Pubmed]
  3. A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D. Paige, A.J., Taylor, K.J., Stewart, A., Sgouros, J.G., Gabra, H., Sellar, G.C., Smyth, J.F., Porteous, D.J., Watson, J.E. Cancer Res. (2000) [Pubmed]
  4. The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis. Kuroki, T., Yendamuri, S., Trapasso, F., Matsuyama, A., Aqeilan, R.I., Alder, H., Rattan, S., Cesari, R., Nolli, M.L., Williams, N.N., Mori, M., Kanematsu, T., Croce, C.M. Clin. Cancer Res. (2004) [Pubmed]
  5. The role of late/slow replication of the FRA16D in common fragile site induction. Palakodeti, A., Han, Y., Jiang, Y., Le Beau, M.M. Genes Chromosomes Cancer (2004) [Pubmed]
  6. Refined physical mapping of chromosome 16-specific low-abundance repetitive DNA sequences. Stallings, R.L., Whitmore, S.A., Doggett, N.A., Callen, D.F. Cytogenet. Cell Genet. (1993) [Pubmed]
  7. A new location for the human adenine phosphoribosyltransferase gene (APRT) distal to the haptoglobin (HP) and fra(16)(q23)(FRA16D) loci. Fratini, A., Simmers, R.N., Callen, D.F., Hyland, V.J., Tischfield, J.A., Stambrook, P.J., Sutherland, G.R. Cytogenet. Cell Genet. (1986) [Pubmed]
  8. WWOX protein expression in normal human tissues. Nunez, M.I., Ludes-Meyers, J., Aldaz, C.M. J. Mol. Histol. (2006) [Pubmed]
  9. WWOX, a chromosomal fragile site gene and its role in cancer. Ramos, D., Aldaz, C.M. Adv. Exp. Med. Biol. (2006) [Pubmed]
WikiGenes - Universities